Clinico-pathological evaluation of oral melanotic macule, oral pigmented nevus and oral mucosal melanoma

Buery, R.R.; Siar, C.H.; Katase, N.; Fujii, M.; Liu, H.; Kubota, M.; Tamamura, R.; Tsujigiwa, H.; Nagatsuka, H. (2010) Clinico-pathological evaluation of oral melanotic macule, oral pigmented nevus and oral mucosal melanoma. Journal of Hard Tissue Biology, 19 (1). pp. 57-64. ISSN 13417649

[img]
Preview
PDF [error in script]
Download (27Kb) | Preview

    Abstract

    Focal pigmented melanocytic lesions rarely occur in the oral cavity but should not be taken for granted for they may represent markers or risks for oral mucosal melanoma (OMM). The study investigated the clinical and pathological features of focal pigmented lesions of melanocytic origin focusing on oral melanotic macule (oral MM), oral pigmented nevus (OPN) and OMM. Immunohistochemistry was employed with S100, HMB-45, Melan A, c-kit and Ki-67. Oral MM mostly occurred on the gingiva and buccal mucosa while OPN mostly occurred on the buccal mucosa. OMM occurred on the palate and gingiva. A female gender predilection was observed in oral MM. Most of the benign lesions were less than 6 mm in diameter while OMM had greater than 10 mm in diameter. Benign lesions occurred in almost the same location as that of OMM. S100 and c-kit were detected in most benign cases while HMB-45 and Melan A were focally detected in some cases. S100, HMB-45 and Melan A expressions were detected in all cases of OMM. Ki-67 was only detected at the epithelial basal layer in oral MM and was completely negative in nevus cells. In OMM, Ki-67 was more than 80. In conclusion, oral MM and OPN may not be markers of risk for OMM but excisional biopsy is highly recommended for clinically undefined lesions greater than 6 mm in diameter. The combination of S100, c-kit, HMB-45 and Melan A can be utilized to support the diagnosis of OMM. © 2010 The Hard Tissue Biology Network Association Printed in Japan.

    Item Type: Article
    Creators:
    1. Buery, R.R.
    2. Siar, C.H.
    3. Katase, N.
    4. Fujii, M.
    5. Liu, H.
    6. Kubota, M.
    7. Tamamura, R.
    8. Tsujigiwa, H.
    9. Nagatsuka, H.
    Journal or Publication Title: Journal of Hard Tissue Biology
    Additional Information: Cited By (since 1996): 1 Export Date: 15 October 2012 Source: Scopus Language of Original Document: English Correspondence Address: Nagatsuka, H.; Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama City 700-8525, Japan; email: jin@md.okayama-u.ac.jp References: Regezi, J., Sciubba, J., Jordan, R., Pigmented lesions (2008) Oral Pathology: Clinical Pathological Correlations, pp. 127-137. , Saunders Elsevier, Missouri; Weathers, D.R., Corio, R.L., Crawford, B.E., Giansanti, J.S., Page, L.R., The labial melanotic macule (1976) Oral Surg Oral Med Oral Pathol, 42, pp. 196-205; Page, L.R., Corio, R.L., Crawford, B.E., Giansanti, J.S., Weathers, D.R., The oral melanotic macule (1977) Oral Surg Oral Med Oral Pathol, 44, pp. 219-226; Kauzman, A., Pavone, M., Blanas, N., Bradley, G., Pigmented lesions of the oral cavity: Review, differential diagnosis, and case presentations (2004) J Can Dent Assoc, 70, pp. 682-683; Buchner, A., Hansen, L.S., Pigmented nevi of the oral mucosa: A clinicopathologic study of 36 new cases and review of 155 cases from the literature. Part II: Analysis of 191 cases (1987) Oral Surg Oral Med Oral Pathol, 63, pp. 676-682; Barker, B.F., Carpenter, W.M., Daniels, T.E., Kahn, M.A., Leider, A.S., Lozada-Nur, F., Lynch, D.P., Young, S.K., Oral mucosal melanomas: The WESTOP Banff workshop proceedings. Western Society of Teachers of Oral Pathology (1997) Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 83, pp. 672-679; Batsakis, J.G., Suarez, P., Mucosal melanomas: A review (2000) Adv Anat Pathol, 7, pp. 167-180; Hicks, M.J., Flaitz, C.M., Oral mucosal melanoma: Epidemiology and pathobiology (2000) Oral Oncol, 36, pp. 152-169; Prasad, M.L., Jungbluth, A.A., Iversen, K., Huvos, A.G., Busam, K.J., Expression of melanocytic differentiation markers in malignant melanomas of the oral and sinonasal mucosa (2001) Am J Surg Pathol, 25, pp. 782-787; Levene, A., On the histological diagnosis and prognosis of malignant melanoma (1980) J Clin Pathol, 33, pp. 101-124; Banerjee, S.S., Harris, M., Morphological and immunophenotypic variations in malignant melanoma (2000) Histopathology, 36, pp. 387-402; Nagatsuka, H., Rivera, R.S., Gunduz, M., Lee, Y.J., Tamamura, R., Gunduz, E., Naito, I., Nagai, N., Immunolocalization and distribution patterns of type IV collagen alpha chains in oral mucosal melanoma (2005) Virchows Arch, 447, pp. 710-716; Rivera, R.S., Nagatsuka, H., Gunduz, M., Cengiz, B., Gunduz, E., Siar, C.H., Tsujigiwa, H., Nagai, N., C-kit protein expression correlated with activating mutations in KIT gene in oral mucosal melanoma (2008) Virchows Arch, 452, pp. 27-32; Bonfrer, J.M., Korse, C.M., Nieweg, O.E., Rankin, E.M., The luminescence immunoassay S-100: A sensitive test to measure circulating S-100B: Its prognostic value in malignant melanoma (1998) Br J Cancer, 77, pp. 2210-2214; Cochran, A.J., Wen, D.R., S-100 protein as a marker for melanocytic and other tumours (1985) Pathology, 17, pp. 340-345; Gown, A.M., Vogel, A.M., Hoak, D., Gough, F., McNutt, M.A., Monoclonal antibodies specific for melanocytic tumors distinguish subpopulations of melanocytes (1986) Am J Pathol, 123, pp. 195-203; Harpio, R., Einarsson, R., S100 proteins as cancer biomarkers with focus on S100B in malignant melanoma (2004) Clin Biochem, 37, pp. 512-518; Jungbluth, A.A., Busam, K.J., Gerald, W.L., Stockert, E., Coplan, K.A., Iversen, K., Macgregor, D.P., Chen, Y.T., A103: An anti-melan-a monoclonal antibody for the detection of malignant melanoma in paraffin-embedded tissues (1998) Am J Surg Pathol, 22, pp. 595-602; Springall, D.R., Gu, J., Cocchia, D., Michetti, F., Levene, A., Levene, M.M., Marangos, P.J., Polak, J.M., The value of S-100 immunostaining as a diagnostic tool in human malignant melanomas. A comparative study using S-100 and neuron-specific enolase antibodies (1983) Virchows Arch a Pathol Anat Histopathol, 400, pp. 331-343; Tanaka, N., Amagasa, T., Iwaki, H., Shioda, S., Takeda, M., Reck, S.F.O.K., Oral malignant melanoma in Japan (1994) Oral Surg Oral Med Oral Pathol, 78, pp. 81-90; Meleti, M., Mooi, W.J., Casparie, M.K., Waal, I.V.D., Melanocytic nevi of the oral mucosa - no evidence of increased risk for oral malignant melanoma: An analysis of 119 cases (2007) Oral Oncol, 43, pp. 976-981; Chidzonga, M.M., Mahomva, L., Marimo, C., Makunike-Mutasa, R., Primary malignant melanoma of the oral mucosa (2007) J Oral Maxillofac Surg, 65, pp. 1117-1120; Meleti, M., Leemans, C.R., Mooi, W.J., Vescovi, P., Waal, I.V.D., Oral malignant melanoma: A review of the literature (2007) Oral Oncol, 43, pp. 116-121; Nakajima, T., Watanabe, S., Sato, Y., Kameya, T., Shimosato, Y., Ishihara, K., Immunohistochemical demonstration of S100 protein in malignant melanoma and pigmented nevus, and its diagnostic application (1982) Cancer, 50, pp. 912-918; Salama, I., Malone, P.S., Mihaimeed, F., Jones, J.L., A review of the S100 proteins in cancer (2008) Eur J Surg Oncol, 34, pp. 3573-3564; Folpe, A.L., Cooper, K., Best practices in diagnostic immunohistochemistry: Pleomorphic cutaneous spindle cell tumors (2007) Arch Pathol Lab Med, 131, pp. 1517-1524; Longacre, T.A., Egbert, B.M., Rouse, R.V., Desmoplastic and spindle-cell malignant melanoma. An immunohistochemical study (1996) Am J Surg Pathol, 20, pp. 1489-1500; Alexeev, V., Yoon, K., Distinctive role of the cKit receptor tyrosine kinase signaling in mammalian melanocytes (2006) J Invest Dermatol, 126, pp. 1102-1110; Grichnik, J.M., Kit and melanocyte migration (2006) J Invest Dermatol, 126, pp. 945-947; Garzino-Demo, P., Fasolis, M., Maggiore, G.M., Pagano, M., Berrone, S., Oral mucosal melanoma: A series of case reports (2004) J Craniomaxillofac Surg, 32, pp. 251-257; de Wit, N.J., van Muijen, G.N., Ruiter, D.J., Immunohistochemistry in melanocytic proliferative lesions (2004) Histopathology, 44, pp. 517-541; Thompson, J.F., Scolyer, R.A., Kefford, R.F., Cutaneous melanoma (2005) Lancet, 365, pp. 687-701
    Uncontrolled Keywords: Immunohistochemistry Melanoma markers Oral melanotic macule Oral mucosal melanoma Oral pigmented nevus
    Subjects: R Medicine > RK Dentistry
    Divisions: Faculty of Dentistry > Dept of Oral Pathology & Oral Medicine & Periodontology
    Depositing User: Ms Nursyafiqah Abd Malek
    Date Deposited: 08 Jan 2013 11:44
    Last Modified: 08 Jan 2013 11:44
    URI: http://eprints.um.edu.my/id/eprint/4276

    Actions (For repository staff only: Login required)

    View Item

    Document Downloads

    More statistics for this item...