Distribution of immunoglobulin classes and IgG subclasses against a culture filtrate antigen of Burkholderia pseudomallei in melioidosis patients.

Chenthamarakshan, V.; Kumutha, M.V.; Vadivelu, J.; Puthucheary, S.D. (2001) Distribution of immunoglobulin classes and IgG subclasses against a culture filtrate antigen of Burkholderia pseudomallei in melioidosis patients. Journal of medical microbiology, 50 (1). pp. 55-61. ISSN 0022-2615

Full text not available from this repository.

Abstract

The class and subclass distribution of antibody response to the culture filtrate antigen (CFA) of Burkholderia pseudomallei was examined in the sera of 45 septicaemic and 17 localised melioidosis cases and 40 cases clinically suspected of melioidosis and the results were compared with those from high-risk and healthy control groups. The geometric mean titre index (GMTI) values for all classes and subclasses of immunoglobulins examined were higher for sera from the proven and clinically suspected melioidosis cases than for the control groups. However, the highest response in the three patient groups was that of IgG with GMTIs ranging from 219.4 to 291.6 and the lowest was for IgM with GMTIs of 22.5, 24.3 and 28.7. The IgA response was intermediate with GMTIs ranging from 119.2 to 170. The GMTIs were highest for IgG in septicaemic and localised infections and for IgA and IgM in localised infections. As regards IgG subclass distribution, IgG1 and IgG2 were the predominant subclasses produced against the CFA in contrast to IgG3 and IgG4, which were produced in low amounts. None of the sera from the control groups had any significant titres of antibodies.

Item Type: Article
Creators:
  1. Chenthamarakshan, V.
  2. Kumutha, M.V.
  3. Vadivelu, J.
  4. Puthucheary, S.D.
Journal or Publication Title: Journal of medical microbiology
Uncontrolled Keywords: Antibodies, Bacterial/blood; Antibody Specificity;
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine
Depositing User: Mr. Faizal Hamzah
Date Deposited: 05 Mar 2011 16:31
Last Modified: 20 Oct 2014 14:47
URI: http://eprints.um.edu.my/id/eprint/426

Actions (For repository staff only: Login required)

View Item