Evaluation of the use of Cocos nucifera as antimalarial remedy in Malaysian folk medicine

Al-Adhroey, A.H. and Nor, Z.M. and Al-Mekhlafi, H.M. and Amran, A.A. and Mahmud, R. (2011) Evaluation of the use of Cocos nucifera as antimalarial remedy in Malaysian folk medicine. Journal of Ethnopharmacology, 134 (3). pp. 988-991. ISSN 0378-8741,

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Abstract

Ethnopharmacological relevance: White flesh extract of Cocos nucifera (coconut) was studied to ascertain the ethnopharmacological standing of its antimalarial usage in Malaysian folk medicine. Materials and methods: The crude methanol extract was investigated for phytochemical constituents and acute oral toxicity. Antimalarial activity of different extract doses of 50, 100, 200 and 400 mg/kg were investigated in vivo against Plasmodium berghei (NK65) infections in mice during early, established and residual infections. Chloroquine (20 mg/kg) and pyrimethamine (1.2 mg/kg) were used as reference drugs. Results: The results revealed that the extract contained some phytochemical constituents and is toxicologically safe by oral administration. The extract significantly reduced the parasitaemia by the 200 and 400 mg/kg doses in the all three in vivo assessment assays. However, the extract did not significantly increase the survival time of the infected mice. Conclusions: The observed pharmacological activities suggest that the Malaysian folkloric medicinal application of Cocos nucifera has a pharmacological basis. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

Item Type: Article
Funders: UNSPECIFIED
Additional Information: Al-Adhroey, Abdulelah H. Nor, Zurainee M. Al-Mekhlafi, Hesham M. Amran, Adel A. Mahmud, Rohela
Uncontrolled Keywords: Cocos nucifera as antimalarial remedy in Malaysian folk medicine
Subjects: R Medicine
Depositing User: Mr. Mohammed Salim Abd Rahman
Date Deposited: 08 Jan 2013 01:55
Last Modified: 08 Jan 2013 01:55
URI: http://eprints.um.edu.my/id/eprint/4230

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