Prasoppokakorn, Thaninee and Chan, Wah-Kheong and Wong, Vincent Wai-Sun and Pitisuttithum, Panyavee and Mahadeva, Sanjiv and Mustapha, Nik Raihan Nik and Wong, Grace Lai-Hung and Leung, Howard Ho-Wai and Sripongpun, Pimsiri and Treeprasertsuk, Sombat (2022) Validation model of fibrosis-8 index score to predict significant fibrosis among patients with nonalcoholic fatty liver disease. World Journal of Gastroenterology, 28 (15). pp. 1563-1573. ISSN 1007-9327, DOI https://doi.org/10.3748/wjg.v28.i15.1563.
Full text not available from this repository.Abstract
BACKGROUND Identifying hepatic fibrosis is crucial for nonalcoholic fatty liver disease (NAFLD) management. The fibrosis-8 (FIB-8) score, recently developed by incorporating four additional variables into the fibrosis-4 (FIB-4) score, showed better performance in predicting significant fibrosis in NAFLD. AIM To validate the FIB-8 score in a biopsy-proven NAFLD cohort and compare the diagnostic performance of the FIB-8 and FIB-4 scores and NAFLD fibrosis score (NFS) for predicting significant fibrosis. METHODS We collected the data of biopsy-proven NAFLD patients from three Asian centers in three countries. All the patients with available variables for the FIB-4 score (age, platelet count, and aspartate and alanine aminotransferase levels) and FIB-8 score (the FIB-4 variables plus 4 additional parameters: The body mass index (BMI), albumin to globulin ratio, gamma-glutamyl transferase level, and presence of diabetes mellitus) were included. The fibrosis stage was scored using nonalcoholic steatohepatitis CRN criteria, and significant fibrosis was defined as at least fibrosis stage 2. RESULTS A total of 511 patients with biopsy-proven NAFLD and complete data were included for validation. Of these 511 patients, 271 (53.0%) were female, with a median age of 51 (interquartile range: 41, 58) years. The median BMI was 29 (26.3, 32.6) kg/m(2), and 268 (52.4%) had diabetes. Among the 511 NAFLD patients, 157 (30.7%) had significant fibrosis (>= F2). The areas under the receiver operating characteristic curves of the FIB-8 and FIB- 4 scores and NFS for predicting significant fibrosis were 0.774, 0.743, and 0.680, respectively. The FIB-8 score demonstrated significantly better performance for predicting significant fibrosis than the NFS (P = 0.001) and was also clinically superior to FIB-4, although statistical significance was not reached (P = 0.073). The low cutoff point of the FIB-8 score for predicting significant fibrosis of 0.88 showed 92.36% sensitivity, and the high cutoff point of the FIB-8 score for predicting significant fibrosis of 1.77 showed 67.51% specificity. CONCLUSION We demonstrated that the FIB-8 score had significantly better performance for predicting significant fibrosis in NAFLD patients than the NFS, as well as clinically superior performance vs the FIB-4 score in an Asian population. A novel simple fibrosis score comprising commonly accessible basic laboratories may be beneficial to use for an initial assessment in primary care units, excluding patients with significant liver fibrosis and aiding in patient selection for further hepatologist referral.
| Item Type: | Article |
|---|---|
| Funders: | Fatty Liver Research Fund, Faculty of Medicine Foundation, Chulalongkorn University |
| Uncontrolled Keywords: | Nonalcoholic fatty liver disease; Fibrosis-8 score; Fibrosis-4 score; Nonalcoholic fatty liver disease fibrosis score |
| Subjects: | R Medicine > R Medicine (General) > Medical technology |
| Divisions: | Faculty of Medicine > Medicine Department |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 18 Oct 2023 06:35 |
| Last Modified: | 18 Oct 2023 06:35 |
| URI: | http://eprints.um.edu.my/id/eprint/42008 |
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