Ward, Sarah and Burton, Anya and Tamimi, Rulla M. and Pereira, Ana and Garmendia, Maria Luisa and Pollan, Marina and Boyd, Norman and dos-Santos-Silva, Isabel and Maskarinec, Gertraud and Perez-Gomez, Beatriz and Vachon, Celine and Miao, Hui and Lajous, Martin and Lopez-Ridaura, Ruy and Bertrand, Kimberly and Kwong, Ava and Ursin, Giske and Lee, Eunjung and Ma, Huiyan and Vinnicombe, Sarah and Moss, Sue and Allen, Steve and Ndumia, Rose and Vinayak, Sudhir and Teo, Soo-Hwang and Mariapun, Shivaani and Peplonska, Beata and Bukowska-Damska, Agnieszka and Nagata, Chisato and Hopper, John and Giles, Graham and Ozmen, Vahit and Aribal, Mustafa Erkin and Schuez, Joachim and Van Gils, Carla H. and Wanders, Johanna O. P. and Sirous, Reza and Sirous, Mehri and Hipwell, John and Kim, Jisun and Lee, Jong Won and Dickens, Caroline and Hartman, Mikael and Chia, Kee-Seng and Scott, Christopher and Chiarelli, Anna M. and Linton, Linda and Flugelman, Anath Arzee and Salem, Dorria and Kamal, Rasha and McCormack, Valerie and Stone, Jennifer (2022) The association of age at menarche and adult height with mammographic density in the International Consortium of Mammographic Density. Breast Cancer Research, 24 (1). ISSN 1465-5411, DOI https://doi.org/10.1186/s13058-022-01545-9.
Full text not available from this repository.Abstract
Background Early age at menarche and tall stature are associated with increased breast cancer risk. We examined whether these associations were also positively associated with mammographic density, a strong marker of breast cancer risk. Methods Participants were 10,681 breast-cancer-free women from 22 countries in the International Consortium of Mammographic Density, each with centrally assessed mammographic density and a common set of epidemiologic data. Study periods for the 27 studies ranged from 1987 to 2014. Multi-level linear regression models estimated changes in square-root per cent density (root PD) and dense area (root DA) associated with age at menarche and adult height in pooled analyses and population-specific meta-analyses. Models were adjusted for age at mammogram, body mass index, menopausal status, hormone therapy use, mammography view and type, mammographic density assessor, parity and height/age at menarche. Results In pooled analyses, later age at menarche was associated with higher per cent density (beta(root PD) = 0.023 SE = 0.008, P = 0.003) and larger dense area (beta(root DA) = 0.032 SE = 0.010, P = 0.002). Taller women had larger dense area (beta(root DA) = 0.069 SE = 0.028, P = 0.012) and higher per cent density (beta(root PD) = 0.044, SE = 0.023, P = 0.054), although the observed effect on per cent density depended upon the adjustment used for body size. Similar overall effect estimates were observed in meta-analyses across population groups. Conclusions In one of the largest international studies to date, later age at menarche was positively associated with mammographic density. This is in contrast to its association with breast cancer risk, providing little evidence of mediation. Increased height was also positively associated with mammographic density, particularly dense area. These results suggest a complex relationship between growth and development, mammographic density and breast cancer risk. Future studies should evaluate the potential mediation of the breast cancer effects of taller stature through absolute breast density.
| Item Type: | Article |
|---|---|
| Funders: | Universiti Malaya [Grant no. UMRG RP046B-15HTM] |
| Uncontrolled Keywords: | Mammographic density; Menarche; Height; Breast cancer |
| Subjects: | R Medicine > RC Internal medicine |
| Divisions: | Universiti Malaya Medical Centre (UMMC) |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 03 Jun 2025 09:01 |
| Last Modified: | 03 Jun 2025 09:01 |
| URI: | http://eprints.um.edu.my/id/eprint/41864 |
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