Cheung, Johnny T. K. and Lau, Eric and Tsui, Cyrus C. T. and Siu, Edmond L. N. and Tse, Naomi K. W. and Hui, Nicole Y. L. and Ma, Ronald C. W. and Kong, Alice P. S. and Fu, Amy and Lau, Vanessa and Jia, Weiping and Sheu, Wayne H. H. and Sobrepena, Leorino and Yoon, K. H. and Tan, Alexander T. B. and Chia, Yook-Chin and Sosale, Aravind and Saboo, Banshi D. and Kesavadev, Jothydev and Goh, Su-Yen and Nguyen, Thy Khue and Thewjitcharoen, Yotsapon and Suwita, Raymond and Luk, Andrea O. Y. and Yang, Aimin and Chow, Elaine and Lim, Lee Ling and Chan, Juliana C. N. (2022) Combined associations of family history and self-management with age at diagnosis and cardiometabolic risk in 86,931 patients with type 2 diabetes: Joint Asia Diabetes Evaluation (JADE) Register from 11 countries. BMC Medicine, 20 (1). ISSN 1741-7015, DOI https://doi.org/10.1186/s12916-022-02424-y.
Full text not available from this repository.Abstract
Background Family history (FamH) of type 2 diabetes might indicate shared genotypes, environments, and/or behaviors. We hypothesize that FamH interacts with unhealthy behaviors to increase the risk of early onset of diabetes and poor cardiometabolic control. Methods In a cross-sectional analysis of the prospective Joint Asia Diabetes Evaluation Register including patients from 427 clinics in 11 Asian countries/regions in 2007-2021, we defined positive FamH as affected parents/siblings and self-management as (1) healthy lifestyles (balanced diet, non-use of alcohol and tobacco, regular physical activity) and (2) regular self-monitoring of blood glucose (SMBG). Results Among 86,931 patients with type 2 diabetes (mean +/- SD age: 56.6 +/- 11.6 years; age at diagnosis of diabetes: 49.8 +/- 10.5 years), the prevalence of FamH ranged from 39.1% to 85.3% in different areas with FamH affecting mother being most common (32.5%). The FamH group (n=51,705; 59.5%) was diagnosed 4.6 years earlier than the non-FamH group mean (95% CI): 47.9 (47.8-48.0) vs. 52.5 (52.4-52.6), logrank p<0.001]. In the FamH group, patients with both parents affected had the earliest age at diagnosis 44.6 (44.5-44.8)], followed by affected single parent 47.7 (47.6-47.8)] and affected siblings only 51.5 (51.3-51.7), logrank p<0.001]. The FamH plus >= 2 healthy lifestyle group had similar age at diagnosis 48.2 (48.1-48.3)] as the non-FamH plus <2 healthy lifestyle group 50.1 (49.8-50.5)]. The FamH group with affected parents had higher odds of hyperglycemia, hypertension, and dyslipidemia than the FamH group with affected siblings, with the lowest odds in the non-FamH group. Self-management (healthy lifestyles plus SMBG) was associated with higher odds of attaining HbA(1c)<7%, blood pressure<130/80mmHg, and LDL-C<2.6 mmol/L especially in the FamH group (FamHxself-management, p(interaction)=0.050-0.001). Conclusions In Asia, FamH was common and associated with young age of diagnosis which might be delayed by healthy lifestyle while self management was associated with better control of cardiometabolic risk factors especially in those with FamH.
| Item Type: | Article |
|---|---|
| Funders: | Asia Diabetes Foundation, CUHK Post-doctoral Fellowship Scheme, Merck & Company |
| Uncontrolled Keywords: | Age of diagnosis; Family history; Type 2 diabetes; Self-management; Cardiometabolic risks |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine > Primary Care Medicine Department |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 19 Oct 2023 07:46 |
| Last Modified: | 19 Oct 2023 07:46 |
| URI: | http://eprints.um.edu.my/id/eprint/41862 |
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