Nissapatorn, V.; Lim, Y.A.; Jamaiah, I.; Agnes, L.S.; Amyliana, K.; Wen, C.C.; Nurul, H.; Nizam, S.; Quake, C.T.; Valartmathi, C.; Woei, C.Y.; Anuar, A.K. (2005) Parasitic infections in Malaysia: changing and challenges. Southeast Asian Journal of Tropical Medicine and Public Health, 36 Sup. pp. 50-59. ISSN 01251562
A total of 1,885 blood and stool samples of four main protozoan parasitic infections were retrospectively reviewed from January, 2000 to April, 2004. Eleven of the 1,350 stool samples were shown positive for Cryptosporidium and Giardia infections; one of the 5 cases was clinically diagnosed as gastrointestinal cryptosporidiosis, while 6 cases were giardiasis. In patients with giardiasis, children were among the high-risk groups, making up 66.7 of these patients. The common presenting signs and symptoms were: diarrhea (83.3), loss of appetite (83.3), lethargy (83.3), fever (66.7), nausea/vomiting (50.0), abdominal pain (16.7), dehydration (16.7) and rigor and chills (16.7). Metronidazole was the drug of choice and was given to all symptomatic patients (83.3). For the blood samples, 28 of the 92 peripheral smears for Plasmodium spp infection were diagnosed as malaria. The age range was from 4 to 57, with a median of 32.5 years. The sex ratio (M:F) was 3.6:1, while the age group of 30-44 years was the most commonly affected in both sexes. The majority of patients were foreigners (60.7) and non-professional (39). Plasmodium vivax (71) infection was the most common pathogen found in these patients, along with a history of traveling to an endemic area of malaria (31). The predominant presenting signs and symptoms were: fever (27), rigor and chills (24), nausea/vomiting (15) and headache (8). Chloroquine and primaquine was the most common anti-malarial regimen used (78.6) in these patients. The seroprevalence of toxoplasmosis in different groups was 258/443 (58): seropositive for IgG 143 (32.3); IgM 67 (15); and IgG + IgM 48 (10.8). The age range was from 1 to 85, with a mean of 34 (+/- SD 16.6) years. The predominant age group was 21 to 40 years (126; 28.4). The sex ratio (M:F) was 1.2:1. Subjects were predominantly male (142; 32) and the Malay (117; 26.4). Of these, 32 cases were clinically diagnosed with ocular toxoplasmosis. The range of age was from 10 to 56 years with a mean of 30.5 (+/- SD 12.05) years. The sex ratio (M:F) was 1:1.7. The majority were in the age group of 21 to 40 years, female (20; 62.5), and Malay (17; 53). They were also single (16; 50), unemployed (12; 37), and resided outside Kuala Lumpur (21; 65.6). The more common clinical presentations were blurring of vision (25; 78), floaters (10; 31) and pain in the eye (7; 22). We found that funduscopic examination (100) and seropositivity for anti-Toxoplasma antibodies (93.7) were the main reasons for investigation. Choroidoretinitis was the most common clinical diagnosis (69), while clindamycin was the most frequently used antimicrobial in all cases. Among HIV-infected patients, 10 cases were diagnosed as AIDS-related toxoplasmic encephalitis (TE) (9 were active and 1 had relapse TE). In addition, 1 case was confirmed as congenital toxoplasmosis.
|Item Type: ||Article|
- Nissapatorn, V.
- Lim, Y.A.
- Jamaiah, I.
- Agnes, L.S.
- Amyliana, K.
- Wen, C.C.
- Nurul, H.
- Nizam, S.
- Quake, C.T.
- Valartmathi, C.
- Woei, C.Y.
- Anuar, A.K.
|Journal or Publication Title: ||Southeast Asian Journal of Tropical Medicine and Public Health|
|Additional Information: ||Cited By (since 1996): 7 Export Date: 15 October 2012 Source: Scopus PubMed ID: 16438180 Language of Original Document: English Correspondence Address: Nissapatorn, V.email: firstname.lastname@example.org|
|Uncontrolled Keywords: ||Adolescent adult age distribution animal article child cryptosporidiosis Cryptosporidium parvum epidemiology female Giardia lamblia giardiasis human isolation and purification malaria Malaysia male middle aged parasitology Plasmodium preschool child protozoal infection sex ratio toxoplasmosis Animals Child, Preschool Humans Protozoan Infections Seroepidemiologic Studies Sex Distribution|
|Subjects: ||R Medicine|
|Divisions: ||Faculty of Medicine|
|Depositing User: ||Miss Malisa Diana|
|Date Deposited: ||12 Dec 2012 12:31|
|Last Modified: ||12 Dec 2012 12:31|
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