Cho, Yoosun and Chang, Yoosoo and Choi, Hye Rin and Kang, Jeonggyu and Kwon, Ria and Lim, Ga-Young and Ahn, Jiin and Kim, Kye-Hyun and Kim, Hoon and Hong, Yun Soo and Zhao, Di and Lekhraj Rampal, Sanjay Rampal and Cho, Juhee and Park, Hyun-Young and Guallar, Eliseo and Ryu, Seungho (2022) Nonalcoholic fatty liver disease and risk of early-onset vasomotor symptoms in lean and overweight premenopausal women. Nutrients, 14 (14). ISSN 2072-6643, DOI https://doi.org/10.3390/nu14142805.
Full text not available from this repository.Abstract
The role of nonalcoholic fatty liver disease (NAFLD) in vasomotor symptom (VMS) risk in premenopausal women is unknown. We examined the prevalence of early-onset VMSs according to NAFLD status in lean and overweight premenopausal women. This cross-sectional study included 4242 premenopausal Korean women (mean age 45.4 years). VMSs (hot flashes and night sweats) were assessed using the Korean version of the Menopause-Specific Quality of Life questionnaire. Hepatic steatosis was determined using liver ultrasound; lean was defined as a body mass index of <23 kg/m(2). Participants were categorized into four groups: NAFLD-free lean (reference), NAFLD-free overweight, lean NAFLD, and overweight NAFLD. Compared with the reference, the multivariable-adjusted prevalence ratios (PRs) (95% confidence intervals (CIs)) for VMSs in NAFLD-free overweight, lean NAFLD, and overweight NAFLD were 1.22 (1.06-1.41), 1.38 (1.06-1.79), and 1.49 (1.28-1.73), respectively. For moderate-to-severe VMSs, the multivariable-adjusted PRs (95% CIs) comparing NAFLD-free overweight, lean NAFLD, and overweight NAFLD to the reference were 1.38 (1.10-1.74), 1.73 (1.16-2.57), and 1.74 (1.37-2.21), respectively. NAFLD, even lean NAFLD, was significantly associated with an increased risk of prevalent early-onset VMSs and their severe forms among premenopausal women. Further studies are needed to determine the longitudinal association between NAFLD and VMS risk.
| Item Type: | Article |
|---|---|
| Funders: | Korea Centers for Disease Control and Prevention (Grant No: 2014ER630200, 2017ER630200, 2020-ER7102-00, 2020ER710201 & 2020ER710202), SKKU Excellence in Research Award Research Fund, Sungkyunkwan University (2020), Korea Health Promotion Institute (Grant No: 2020-ER7102-00) |
| Uncontrolled Keywords: | Menopause; Vasomotor symptoms; Lean; Nonalcoholic fatty liver disease |
| Subjects: | R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine |
| Divisions: | Faculty of Medicine > Social & Preventive Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 27 Nov 2023 01:35 |
| Last Modified: | 27 Nov 2023 01:35 |
| URI: | http://eprints.um.edu.my/id/eprint/41652 |
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