Cheok, Yi Ying and Tan, Grace Min Yi and Lee, Chalystha Yie Qin and Abdullah, Suhailah and Looi, Chung Yeng and Wong, Won Fen (2022) Innate immunity crosstalk with Helicobacter pylori: Pattern recognition receptors and cellular responses. International Journal of Molecular Sciences, 23 (14). ISSN 1661-6596, DOI https://doi.org/10.3390/ijms23147561.
Full text not available from this repository.Abstract
Helicobacter pylori is one of the most successful gastric pathogens that has co-existed with human for centuries. H. pylori is recognized by the host immune system through human pattern recognition receptors (PRRs), such as toll-like receptors (TLRs), C-type lectin like receptors (CLRs), NOD-like receptors (NLRs), and RIG-I-like receptors (RLRs), which activate downstream signaling pathways. Following bacterial recognition, the first responders of the innate immune system, including neutrophils, macrophages, and dendritic cells, eradicate the bacteria through phagocytic and inflammatory reaction. This review provides current understanding of the interaction between the innate arm of host immunity and H. pylori, by summarizing H. pylori recognition by PRRs, and the subsequent signaling pathway activation in host innate immune cells.
| Item Type: | Article |
|---|---|
| Funders: | Malaysia Ministry of Higher Education Fundamental Research Grant Scheme (Grant No: FRGS/1/2019/SKK06/UM/02/4 (FP133-2019A)), Institut Merieux Young Investigator Fund (Grant No: IF039-2017), Malaysia Public Service Department |
| Uncontrolled Keywords: | Helicobacter pylori; Innate immune activation; Pattern recognition receptors; TLRs; CLRs; NLRs; RLRs; Macrophages |
| Subjects: | Q Science > QR Microbiology |
| Divisions: | Faculty of Medicine Faculty of Medicine > Medicine Department |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 27 Oct 2023 07:52 |
| Last Modified: | 27 Oct 2023 07:52 |
| URI: | http://eprints.um.edu.my/id/eprint/41651 |
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