Ooi, Choo Huck and Phang, Wei Kit and Liew, Jonathan Wee Kent and Atroosh, Wahib M. and Lau, Yee Ling (2022) Epidemiology of indigenous Plasmodium knowlesi infection in Sarawak, 2011-2019. Tropical Medicine and International Health, 27 (8). pp. 705-718. ISSN 1360-2276, DOI https://doi.org/10.1111/tmi.13788.
Full text not available from this repository.Abstract
Objectives To characterise the state-wide epidemiology of indigenous knowlesi malaria in Sarawak from 2011 to 2019. Methods Longitudinal retrospective study was conducted based on Sarawak knowlesi malaria surveillance data recorded from 2011-2019. Only indigenous cases were included and information extracted for analysis comprised age, sex, occupation, ethnicity, case severity, hospital admission and parasite density. Results Over the 9 years, 8473 indigenous knowlesi malaria cases were recorded. Age group 40-49 years, males, plantation workers and Iban communities recorded the highest percentage of cases in each demographic variable. Most of the cases were uncomplicated (n = 7292; 86.1%) and 89.6% (n = 7589) of the total cases were reported with <= 20 000 parasites/mu l of blood. Age group and ethnic group are associated with the severity of knowlesi malaria in Sarawak. Multivariable logistic regression indicated that the age group 60+ years had the highest odds of developing severe knowlesi malaria compared with other age groups (AOR 2.48; 95% CI 1.22, 5.02; p = 0.012). Bidayuh patients were more likely to develop severe knowlesi malaria than Ibans, the largest ethnic group among knowlesi malaria patients (AOR 1.97; 95% CI 1.31, 2.97; p = 0.001). Conclusions Identification of risk groups is important for the implementation of prevention programs and treatments targeting at specific group to combat knowlesi malaria effectively.
| Item Type: | Article |
|---|---|
| Funders: | Director General of Health Malaysia, Sarawak Health Department, LR002D-2018, LRGS/1/2018/UM/01/1/4, Ministry of Higher Education, Malaysia, Kementerian Kesihatan Malaysia |
| Uncontrolled Keywords: | Demographic risk factors; Malaria; Malaysia; Plasmodium knowlesi; Sarawak |
| Subjects: | R Medicine > RA Public aspects of medicine R Medicine > RC Internal medicine |
| Divisions: | Faculty of Medicine > Parasitology Deparment |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 22 Nov 2023 08:30 |
| Last Modified: | 22 Nov 2023 08:30 |
| URI: | http://eprints.um.edu.my/id/eprint/41635 |
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