Production and first use of (SmCl3)-Sm-153-ion exchange resin capsule formulation for assessing gastrointestinal motility

Yeong, C.H. and Abdullah, B.J.J. and Ng, K.H. and Chung, L.Y. and Goh, K.L. and Sarji, S.A. and Perkins, A.C. (2012) Production and first use of (SmCl3)-Sm-153-ion exchange resin capsule formulation for assessing gastrointestinal motility. Applied Radiation and Isotopes, 70 (3). pp. 450-455. ISSN 0969-8043

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Abstract

We produced an enteric-coated gelatine capsule containing neutron-activated Sm-153-labelled resin beads for use in gastrointestinal motility studies. In vitro test in simulated gastrointestinal environment and in vivo study on volunteers were performed. Scintigraphic images were acquired from ten volunteers over 24 h while blood and urine samples were collected to monitor the presence of Sm-153. All the capsules remained intact in stomach. This proved to be a safe and practical oral capsule formulation for whole gut transit scintigraphy. (C) 2011 Elsevier Ltd. All rights reserved.

Item Type: Article
Additional Information: ISI Document Delivery No.: 905YM Times Cited: 0 Cited Reference Count: 24 Cited References: Agachan F, 1996, DIS COLON RECTUM, V39, P681, DOI 10.1007/BF02056950 Ahrabi SF, 1999, EUR J PHARM SCI, V8, P193, DOI 10.1016/S0928-0987(99)00015-9 Ahrabi SF, 2000, EUR J PHARM SCI, V10, P225, DOI 10.1016/S0928-0987(00)00070-1 Ahrabi SF, 1999, DRUG DEV IND PHARM, V25, P453, DOI 10.1081/DDC-100102195 Akhgari A, 2006, INT J PHARM, V320, P137, DOI 10.1016/j.ijpharm.2006.05.011 AWANG MB, 1993, J LABELLED COMPD RAD, V33, P941, DOI 10.1002/jlcr.2580331008 Cheng G, 2004, WORLD J GASTROENTERO, V10, P1769 Cole ET, 2002, INT J PHARM, V231, P83, DOI 10.1016/S0378-5173(01)00871-7 DIGENIS GA, 1991, CRIT REV THER DRUG, V7, P309 Fani M, 2002, APPL RADIAT ISOTOPES, V57, P665, DOI 10.1016/S0969-8043(02)00181-1 Ibekwe VC, 2006, INT J PHARM, V308, P52, DOI 10.1016/j.ijpharm.2005.10.038 Khan MZI, 2000, DRUG DEV IND PHARM, V26, P549, DOI 10.1081/DDC-100101266 Khan MZI, 1999, J CONTROL RELEASE, V58, P215, DOI 10.1016/S0168-3659(98)00151-5 Kotagale N., 2009, PHARM DEV TECHNOL Lin HC, 2005, DIGEST DIS SCI, V50, P989, DOI 10.1007/s10620-005-2694-6 Marvola J, 2004, INT J PHARM, V281, P3, DOI 10.1016/j.ijpharm.2004.05.022 Marvola T, 2008, INT J PHARM, V349, P24, DOI 10.1016/j.ijpharm.2007.07.033 Mettler FA, 2008, RADIOLOGY, V248, P254, DOI 10.1148/radiol.2481071451 Moustafine RI, 2008, EUR J PHARM BIOPHARM, V70, P215, DOI 10.1016/j.ejpb.2008.04.008 Perkins AC, 2001, INT J PHARM, V222, P295, DOI 10.1016/S0378-5173(01)00722-0 TSE JW, 1989, J NUCL MED, V30, P202 WILDING IR, 1992, PHARMACEUT RES, V9, P1436, DOI 10.1023/A:1015858829187 Yeong CH, 2011, APPL RADIAT ISOTOPES, V69, P1181, DOI 10.1016/j.apradiso.2011.04.017 Yeong CH, 2011, NUCL MED COMMUN, V32, P1256, DOI 10.1097/MNM.0b013e32834b3ac8 Yeong, Chai-Hong Abdullah, Basri Johan Jeet Ng, Kwan-Hoong Chung, Lip-Yong Goh, Khean-Lee Sarji, Sazilah Ahmad Perkins, Alan Christopher University of MalayaPS494/2010B; Ministry of Higher Education, MalaysiaFP067/2010B; Malaysian Nuclear Agency This study was funded by the University of Malaya Postgraduate Research Fund PS494/2010B and Fundamental Research Grant Scheme FP067/2010B from Ministry of Higher Education, Malaysia. The neutron activation was supported by the Malaysian Nuclear Agency. We are grateful to Rehir Dahalan, Zulkifli Hashim and Julia Abdul Karim for their technical support in neutron activation. Pergamon-elsevier science ltd Oxford
Uncontrolled Keywords: Sm-153 Ion-exchange resin Neutron activation Scintigraphic imaging Whole gut transit drug-delivery-system methacrylic-acid copolymers neutron-activation factors gamma-scintigraphy eudragit(r) l100-55 s100 combinations colonic delivery dosage forms sm-153 manipulation
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Mr Ahmad Azwan Azman
Date Deposited: 07 Jan 2013 02:48
Last Modified: 07 Jan 2013 02:48
URI: http://eprints.um.edu.my/id/eprint/4147

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