Zainal-Abidin, Mohamad Hamdi and Hayyan, Maan and Ngoh, Gek Cheng and Wong, Won Fen and Tok, Tugba Taskin (2022) Derivation of an anti-cancer drug nanocarrier using a malonic acid-based deep eutectic solvent as a functionalization agent. Journal of Drug Delivery Science and Technology, 75. ISSN 1773-2247, DOI https://doi.org/10.1016/j.jddst.2022.103657.
Full text not available from this repository.Abstract
Deep eutectic solvents (DESs) are novel `green' solvents that have recently gained considerable interest from diverse sectors of the scientific community. They are considered biocompatible, chemically stable, biodegradable, low-volatility, and non-flammable. In addition, the physicochemical properties of DESs are highly tunable and can be customized to meet the needs of a particular mission, including for its novel application in drug delivery systems. Here, graphene functionalized with the DES choline chloride:malonic acid was investigated for anti-cancer activity after loading with the drug doxorubicin. The DES-functionalized graphene demonstrated high drug loading efficiency and exhibited destructive effects against cancerous cells. Real-time cell growth analysis confirmed its cytotoxicity against cancerous cells over time. All told, the combination of choline chloride and malonic acid shows great promise as a green functionalizing agent for a nano-drug carrier, owing to its lower cytotoxicity, higher doxorubicin loading capacity, and inhibition of cancer cell growth profile.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Ionic liquid; Drug delivery; Doxorubicin; Computational simulation; Graphene; Chemotherapy |
| Subjects: | R Medicine R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 19 Sep 2023 07:41 |
| Last Modified: | 19 Sep 2023 07:41 |
| URI: | http://eprints.um.edu.my/id/eprint/41344 |
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