Single-dose diethylcarbamazine in the control of periodic brugian filariasis in Peninsular Malaysia

Hakim, S.L.; Vythilingam, I.; Marzukhi, M.I.; Mak, J.W. (1995) Single-dose diethylcarbamazine in the control of periodic brugian filariasis in Peninsular Malaysia. Transactions of the Royal Society of Tropical Medicine and Hygiene, 89 (6). pp. 686-689. ISSN 0035-9203

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    Abstract

    The study compared the effectiveness of a single dose of diethylcarbamazine (DEC) (6mg/kg) with the standard regimen of 6 doses (total 36mg/kg) in mass chemotherapy for the control of brugian filariasis. Mass chemotherapy with single-dose DEC was instituted in one area and standard dose in the other and treatment was repeated after one year. Parasitplogical surveys were conducted before, and 3, 7 and 12 months after treatment. Pretreatment characteristics were not significantly different between the 2 treatment areas. There was a significant reduction in microfilaraemia prevalence rate from 24.7 to 14.7 at 12 months and to 6.8 at 19 months in the single dose area and from 22.8 to 9.6 at 12 months and to 2.7 at 19 months with the standard dose. Maximum reduction was at 7 months after treatment with both regimens. There was also significant progressive reduction in mean microfilarial density from 4.39 ± 20.37 to 0.89 ± 4.16 per 60 μL in the single-dose area and from 4.43 ± 17.31 to 0.75 ± 4.95 per 60 μL in the standard dose area. There was a greater reduction of both microfilarial prevalence and density using the standard regimen but it was not statistically significant. Thus, a single dose of DEC is as effective as the standard dose in controlling periodic brugian filariasis.

    Item Type: Article
    Creators:
    1. Hakim, S.L.
    2. Vythilingam, I.(Department of Parasitology, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA)
    3. Marzukhi, M.I.
    4. Mak, J.W.
    Journal or Publication Title: Transactions of the Royal Society of Tropical Medicine and Hygiene
    Additional Information: Department of Parasitology, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA
    Uncontrolled Keywords: Filariasis, Brugia malayi, diethylcarbamazine, single dose therapy, Malaysia
    Subjects: R Medicine
    Divisions: Faculty of Medicine
    Depositing User: Miss Nur Jannatul Adnin Ahmad Shafawi
    Date Deposited: 12 Dec 2012 12:09
    Last Modified: 12 Dec 2012 12:09
    URI: http://eprints.um.edu.my/id/eprint/4129

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