International recommendations for plasma Epstein-Barr virus DNA measurement in nasopharyngeal carcinoma in resource-constrained settings: Lessons from the COVID-19 pandemic

Lee, Victor Ho-Fun and Adham, Marlinda and Ben Kridis, Wala and Bossi, Paolo and Chen, Ming-Yuan and Chitapanarux, Imjai and Gregoire, Vincent and Hao, Sheng Po and Ho, Cheryl and Ho, Gwo Fuang and Kannarunimit, Danita and Kwong, Dora Lai-Wan and Lam, Ka-On and Lam, Wai Kei Jacky and Le, Quynh-Thu and Lee, Anne Wing-Mui and Lee, Nancy Y. and Leung, To-Wai and Licitra, Lisa and Lim, Darren Wan-Teck and Lin, Jin-Ching and Loh, Kwok Seng and Lou, Pei-Jen and Machiels, Jean-Pascal and Mai, Hai-Qiang and Mesia, Ricard and Ng, Wai-Tong and Ngan, Roger Kai-Cheong and Tay, Joshua K. and Tsang, Raymond King-Yin and Tong, Chi-Chung and Wang, Hung-Ming and Wee, Joseph T. (2022) International recommendations for plasma Epstein-Barr virus DNA measurement in nasopharyngeal carcinoma in resource-constrained settings: Lessons from the COVID-19 pandemic. Lancet Oncology, 23 (12). E544-E551. ISSN 1470-2045,

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Abstract

The effects of the COVID-19 pandemic continue to constrain health-care staff and resources worldwide, despite the availability of effective vaccines. Aerosol-generating procedures such as endoscopy, a common investigation tool for nasopharyngeal carcinoma, are recognised as a likely cause of SARS-CoV-2 spread in hospitals. Plasma Epstein-Barr virus (EBV) DNA is considered the most accurate biomarker for the routine management of nasopharyngeal carcinoma. A consensus statement on whether plasma EBV DNA can minimise the need for or replace aerosol-generating procedures, imaging methods, and face-to-face consultations in managing nasopharyngeal carcinoma is urgently needed amid the current pandemic and potentially for future highly contagious airborne diseases or natural disasters. We completed a modified Delphi consensus process of three rounds with 33 international experts in otorhinolaryngology or head and neck surgery, radiation oncology, medical oncology, and clinical oncology with vast experience in managing nasopharyngeal carcinoma, representing 51 international professional societies and national clinical trial groups. These consensus recommendations aim to enhance consistency in clinical practice, reduce ambiguity in delivering care, and offer advice for clinicians worldwide who work in endemic and non-endemic regions of nasopharyngeal carcinoma, in the context of COVID-19 and other airborne pandemics, and in future unexpected settings of severe resource constraints and insufficiency of personal protective equipment.

Item Type: Article
Funders: None
Uncontrolled Keywords: Infection; BNT162B2; Workers; Vaccine
Subjects: R Medicine > RA Public aspects of medicine
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 24 Nov 2023 02:09
Last Modified: 03 Dec 2023 01:23
URI: http://eprints.um.edu.my/id/eprint/41283

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