Kim, Go Wun and Nam, Jae-Sik and Zainal Abidin, Mohd Fitry and Kim, Seon-Ok and Chin, Ji-Hyun and Lee, Eun-Ho and Choi, In-Cheol (2022) Impact of body mass index and sarcopenia on short- and long-term outcomes after esophageal cancer surgery: An observational study. Annals of Surgical Oncology, 29 (11). pp. 6871-6881. ISSN 1068-9265, DOI https://doi.org/10.1245/s10434-022-11944-z.
Full text not available from this repository.Abstract
The effects of specific body mass index (BMI) category and sarcopenia within each BMI category on outcomes in patients undergoing esophageal surgery with esophageal squamous cell carcinoma have not been thoroughly examined. Methods This study included 1141 patients. Sarcopenia was determined with a total psoas muscle cross-sectional area at the level of the third lumbar vertebra in computed tomography. The outcomes were long-term survival, including overall survival (OS) and recurrence-free survival (RFS), and postoperative complications. Results The overweight and no sarcopenia group was considered as the reference. After adjusting covariates, the underweight and the normal weight and sarcopenia groups both showed worse OS (underweight group: hazard ratio HR] 2.04, 95% confidence interval CI] 1.33-3.13, p = 0.001; normal weight and sarcopenia group: HR 1.93, 95% CI 1.39-2.69, p < 0.001) and worse RFS (underweight group: HR 1.78, 95% CI 1.19-2.67, p = 0.005; normal weight and sarcopenia group: HR 1.70, 95% CI 1.25-2.30, p = 0.001). In addition, the underweight group (odds ratio OR] 4.74, 95% CI 2.05-10.96, p < 0.001), the normal weight and sarcopenia group (OR 3.26, 95% CI 1.60-6.62, p = 0.001), the overweight and sarcopenia group (OR 2.54, 95% CI 1.14-5.68, p = 0.023), and the obese and no sarcopenia group (OR 2.44, 95% CI 1.14-5.22, p = 0.021) were at significantly higher risk of postoperative 30-day composite complications. Conclusions Compared with the overweight and no sarcopenia group, the underweight and the normal weight and sarcopenia groups were associated with worse short- and long-term outcomes.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Body Mass Index (BMI); Squamous-cell carcinoma; Obesity paradox; Association |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 15 Sep 2023 03:16 |
| Last Modified: | 15 Sep 2023 03:16 |
| URI: | http://eprints.um.edu.my/id/eprint/41246 |
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