Zoonotic infection caused by Onchocerca japonica (Nematoda: Filarioidea) in a 69-year-old woman in Kanto Region, Eastern Honshu, Japan

Okazaki, Daijiro and Fukuda, Masako and Hebisawa, Akira and Uni, Shigehiko and Junker, Kerstin and Suzuki, Yoshio and Nakano, Michiyo and Agatsuma, Takeshi and Hasegawa, Hideo and Yamada, Minoru and Nakatani, Jun and Hara, Tatsuru and Martin, Coralie and Kimura, Daisuke and Takaoka, Hiroyuki (2022) Zoonotic infection caused by Onchocerca japonica (Nematoda: Filarioidea) in a 69-year-old woman in Kanto Region, Eastern Honshu, Japan. Parasitology International, 91. ISSN 1383-5769, DOI https://doi.org/10.1016/j.parint.2022.102643.

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Abstract

Reports of zoonotic infections caused by the filarial nematode Onchocerca japonica have recently increased in Japan. A 69-year-old woman living in Sosa City, Chiba Prefecture, Kanto Region, Honshu, developed a painful nodule at the metacarpophalangeal joint of the index finger of her right hand. The causative agent was identified as a female O. japonica based on the histopathological characteristics (i.e., cuticle with transverse triangular ridges but without inner striae) of the biopsy specimens of the nodule. The species identification was corrobo-rated by cox1 gene sequencing of the worm tissues isolated from paraffin-embedded sections of the specimens. Subsequent to the excision of the nodule, followed by anthelmintic treatment, the patient remained asymp-tomatic. Human infection with O. japonica has not previously been reported in Kanto Region, Eastern Honshu. The present case is likely linked to the recent expansion of the geographic range of the Japanese wild boar into this area.

Item Type: Article
Funders: UNSPECIFIED
Uncontrolled Keywords: Emerging infectious disease; Filariae; Japanese wild boar; Mitochondrial cox 1 sequencing; Onchocercosis; Transverse ridges
Subjects: R Medicine
R Medicine > R Medicine (General)
Divisions: Deputy Vice Chancellor (Research & Innovation) Office > Tropical Infectious Diseases Research and Education Centre
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 13 Sep 2023 03:09
Last Modified: 13 Sep 2023 03:09
URI: http://eprints.um.edu.my/id/eprint/41191

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