Yap, Chee-Sum Alvin and Razif, Muhammad Fazril Mohamad and Ng, Szu-Ting and Tan, Chon-Seng and Abd Jamil, Amira Hajirah and Fung, Shin-Yee (2022) Anti-oxidative effects of functional food, Lignosus rhinocerus sclerotia (TM02? cultivar) using a type 2 diabetes mellitus rodent model. Food Bioscience, 49. ISSN 2212-4292, DOI https://doi.org/10.1016/j.fbio.2022.101944.
Full text not available from this repository.Abstract
Lignosus rhinocerus is a highly valued medicinal mushroom traditionally consumed by the indigenous commu-nities of Southeast Asia as treatment for numerous ailments, some of which are linked to its antioxidative ac-tivities. While the antioxidative capacity of L. rhinocerus has been established in vitro, lack of translational studies are available on the effect of L. rhinocerus in the pathogenesis of diseases driven by high oxidative stress. This study aims to investigate the in vivo antioxidative effects of cultivated Lignosus rhinocerus (TM02 (R)) sclerotia in a multifaceted in vivo model of oxidative stress, induced by chronic hyperglycemia associated with diabetes. A type 2 diabetes mellitus (T2DM) rodent model was generated using a high-fat diet in combination with low dose streptozotocin after which TM02 (R) cultivar, at a dose of 200 mg/kg, was administered orally for 14 days. Diabetic rats treated with TM02 (R) cultivar had decreased plasma AGEs concentration, complemented with improved mitochondrial respiratory function associated with elevated cardiac and skeletal muscle ATP concentrations in both diabetic and non diabetic rats. Interestingly, TM02 (R) cultivar-treated rats have improved glycemic control, with the potential ability to induce insulin secretion. Our findings revealed that TM02 (R) exhibits antioxidative effects to potentially alleviate diabetes-related complications associated with AGEs accumulation, with signifi-cant effects in enhancing mitochondrial function and energy production.
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Higher Education (MOHE) , Malaysia [FRGS/1/2020/STG02/UM/02/1], Universiti Malaya, LiGNO Research Initiative, LiGNO Biotech Sdn Bhd |
| Uncontrolled Keywords: | Lignosus rhinocerus; TM02? cultivar; Anti-oxidative; ATP; Advanced glycation end products |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 12 Sep 2023 07:16 |
| Last Modified: | 12 Sep 2023 07:16 |
| URI: | http://eprints.um.edu.my/id/eprint/41182 |
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