Sulaiman, Mazdida and Jannat, Khoshnur and Nissapatorn, Veeranoot and Rahmatullah, Mohammed and Paul, Alok K. and Pereira, Maria de Lourdes and Rajagopal, Mogana and Suleiman, Monica and Butler, Mark S. and Bin Break, Mohammed Khaled and Weber, Jean-Frederic and Wilairatana, Polrat and Wiart, Christophe (2022) Antibacterial and antifungal alkaloids from Asian angiosperms: Distribution, mechanisms of action, structure-activity, and clinical potentials. Antibiotics-Basel, 11 (9). ISSN 2079-6382, DOI https://doi.org/10.3390/antibiotics11091146.
Full text not available from this repository.Abstract
The emergence of multidrug-resistant bacteria and fungi requires the development of antibiotics and antifungal agents. This review identified natural products isolated from Asian angiosperms with antibacterial and/or antifungal activities and analyzed their distribution, molecular weights, solubility, and modes of action. All data in this review were compiled from Google Scholar, PubMed, Science Direct, Web of Science, ChemSpider, PubChem, and a library search from 1979 to 2022. One hundred and forty-one antibacterial and/or antifungal alkaloids were identified during this period, mainly from basal angiosperms. The most active alkaloids are mainly planar, amphiphilic, with a molecular mass between 200 and 400 g/mol, and a polar surface area of about 50 A(2), and target DNA and/or topoisomerase as well as the cytoplasmic membrane. 8-Acetylnorchelerythrine, cryptolepine, 8-hydroxydihydrochelerythrine, 6-methoxydihydrosanguinarine, 2 `-nortiliacorinine, pendulamine A and B, rhetsisine, sampangine, tiliacorine, tryptanthrin, tylophorinine, vallesamine, and viroallosecurinine yielded MIC <= 1 mu g/mL and are candidates for the development of lead molecules.
| Item Type: | Article |
|---|---|
| Funders: | Malaysian Ministry of Education [FRGS/1/2018/WAB07/UNIM/02/1], Project CICECOAveiro Institute of Materials - FCT/MEC (PIDDAC) [UIDB/50011/2020] [UIDP/50011/2020] [LA/P/0006/2020] |
| Uncontrolled Keywords: | Medicinal plants; Antibacterial; Antifungal; Alkaloids; Asia |
| Subjects: | Q Science > QD Chemistry R Medicine |
| Divisions: | Faculty of Science |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 08 Sep 2023 06:25 |
| Last Modified: | 08 Sep 2023 06:25 |
| URI: | http://eprints.um.edu.my/id/eprint/41151 |
Actions (login required)
 |
View Item |
