Nordin, Rosmarina and Roslan, Muhammad Aidil and Fathilah, A. R. and Ngui, Romano and Musa, Sabri (2022) Evaluation of in vitro antifungal effects of synthetic and herbal mouth rinses on oral Candida albicans and Candida glabrata. Tropical Biomedicine, 39 (3). pp. 302-314. ISSN 2521-9855, DOI https://doi.org/10.47665/tb.39.3.001.
Full text not available from this repository.Abstract
Mouth rinses which function as breath fresheners, medicaments, and antiseptics can also deliver oral therapeutic agents. This study evaluated and compared the antifungal effects of synthetic and herbal mouth rinses on oral C. albicans and C. glabrata via disk diffusion, minimal inhibition concentration (MIC), minimum fungicidal concentration (MFC), time-kill assay, and growth profile tests. The four chemical mouth rinses, namely Brand O (A), Brand M (B), Brand H (C), and Brand B (D) used in the study showed positive antifungal activity in these two species. The average diameter of the inhibition zones obtained from the disk diffusion test was higher in mouth rinse B (C. albicans = 12.0 +/- 0.9 mm, C. glabrata = 13.5 +/- 0.8 mm) compared to those in C, A and D. Both Candida species exhibited similar MIC and MFC values, ranging from 1.63 +/- 0.5 to 18.75 +/- 0.0 mu g/mL and 6.51 +/- 2.01 to 50.00 +/- 9.36 mu g/mL, respectively. These synthetic mouth rinses had efficient killing activity eliminating 50% of the growing population of both Candida spp. following 15 seconds exposure time. Analyses of the growth profile curves showed that mouth rinses B and A resulted in rapid growth depletion of both Candida spp. Meanwhile, three herbal mouth rinses, namely Brand S (E), Brand C (F), and Brand P (G), were less effective against C. albicans and C. glabrata. Mouth rinses B and A contained cetylpyridinium chloride and chlorhexidine, respectively, and could be an effective alternative for controlling and preventing oral candidiasis.
| Item Type: | Article |
|---|---|
| Funders: | Universiti Malaya [P0037/2008A], Balai Ungku Aziz Research Laboratory, Faculty of Dentistry, Universiti Malaya |
| Uncontrolled Keywords: | Antifungal effects; Synthetic mouth rinses; Herbal mouth rinses; Candida albicans; Candida glabrata |
| Subjects: | R Medicine R Medicine > RK Dentistry |
| Divisions: | Faculty of Dentistry |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 08 Sep 2023 04:01 |
| Last Modified: | 08 Sep 2023 04:01 |
| URI: | http://eprints.um.edu.my/id/eprint/41147 |
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