Lee, Wenn Chyau and Russell, Bruce and Renia, Laurent (2022) Evolving perspectives on rosetting in malaria. Trends In Parasitology, 38 (10). pp. 882-889. ISSN 1471-4922, DOI https://doi.org/10.1016/j.pt.2022.08.001.
Full text not available from this repository.Abstract
The ability of the intraerythrocytic Plasmodium spp. to form spontaneous rosettes with uninfected red blood cells (URBCs) has been observed in the medically im-portant malaria parasites. Since the discovery of rosettes in the late 1980s, differ-ent formation mechanisms and pathobiological roles have been postulated for rosetting; most of which have focused on Plasmodium falciparum. Recent break-throughs, including new data from Plasmodium vivax, have highlighted the multi-faceted roles of rosetting in the immunopathobiology and the development of drug resistance in human malaria. Here, we provide new perspectives on the for-mation and the role of rosetting in malaria rheopathobiology.
| Item Type: | Article |
|---|---|
| Funders: | Open Fund -Young Individual Research grant by the National Medical Research Council (NMRC) , Singapore (OF-YIRG NMRC/OFYIRG/0070/2018), Long Term Research Grant Scheme (LRGS) of the Ministry of Higher Education, Malaysia (LRGS/1/2018/UM/01/1/1), Agency for Science Technology & Research (A*STAR) (JCO-DP BMSI/15-800006), HRC e -ASIA grant (17/678), University of Otago Deans Bequest Grant |
| Uncontrolled Keywords: | Rosetting; Malaria; Red blood cells; Membrane protein |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine > Parasitology Deparment |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 15 Aug 2023 02:55 |
| Last Modified: | 15 Aug 2023 02:55 |
| URI: | http://eprints.um.edu.my/id/eprint/41065 |
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