Nipah virus: a recently emergent deadly paramyxovirus

Chua, K.B. and Bellini, W.J. and Rota, P.A. and Harcourt, B.H. and Tamin, A. and Lam, S.K. and Ksiazek, T.G. and Rollin, P.E. and Zaki, S.R. and Shieh, W. and Goldsmith, C.S. and Gubler, D.J. and Roehrig, J.T. and Eaton, B. and Gould, A.R. and Olson, J. and Field, H. and Daniels, P. and Ling, A.E. and Peters, C.J. and Anderson, L.J. and Mahy, B.W. (2000) Nipah virus: a recently emergent deadly paramyxovirus. Science, 288 (5470). pp. 1432-1435. ISSN 1095-9203

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Official URL: http://science.sciencemag.org/content/288/5470/143...

Abstract

A paramyxovirus virus termed Nipah virus has been identified as the etiologic agent of an outbreak of severe encephalitis in people with close contact exposure to pigs in Malaysia and Singapore. The outbreak was first noted in late September 1998 and by mid-June 1999, more than 265 encephalitis cases, including 105 deaths, had been reported in Malaysia, and 11 cases of encephalitis or respiratory illness with one death had been reported in Singapore. Electron microscopic, serologic, and genetic studies indicate that this virus belongs to the family Paramyxoviridae and is most closely related to the recently discovered Hendra virus. We suggest that these two viruses are representative of a new genus within the family Paramyxoviridae. Like Hendra virus, Nipah virus is unusual among the paramyxoviruses in its ability to infect and cause potentially fatal disease in a number of host species, including humans.

Item Type: Article
Uncontrolled Keywords: Animals; Antibodies, Viral/blood; Disease Outbreaks
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine
Depositing User: Mr. Faizal Hamzah
Date Deposited: 05 Mar 2011 01:47
Last Modified: 23 Oct 2018 06:38
URI: http://eprints.um.edu.my/id/eprint/410

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