Villabona-Arenas, Christian Julián; Zanotto, Paolo Marinho de Andrade (2011) Evolutionary history of Dengue virus type 4: Insights into genotype phylodynamics. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases. ISSN 1567-7257
Full text not available from this repository.Abstract
Dengue virus type four (DENV-4) circulates in tropical and subtropical countries from Asia and the Americas. Despite the importance of dengue virus distribution, little is known about the worldwide viral spread. Following a Bayesian phylogenetic approach we inferred the evolutionary history of 310 isolates sampled from 37 countries during the time period 1956-2008 and the spreading dynamics for genotypes I and II. The region (tropical rainforest biome) comprised by Malaysia-Thailand was the most likely ancestral area from which the serotype has originated and spread. Interestingly, cross-correlation analysis on demographic time series with the Asian sequences showed a statistically significant negative correlation that could be suggestive of competition among genotypes within the same serotype.
| Item Type: | Article |
|---|---|
| Creators: | |
| Journal or Publication Title: | Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases |
| Uncontrolled Keywords: | dengue; |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine > School of Medicine |
| Depositing User: | Zanaria Saupi Udin |
| Date Deposited: | 25 Feb 2011 09:45 |
| Last Modified: | 28 Jul 2011 12:06 |
| URI: | http://eprints.um.edu.my/id/eprint/41 |
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