Evolutionary history of Dengue virus type 4: Insights into genotype phylodynamics.

Villabona-Arenas, Christian Julián; Zanotto, Paolo Marinho de Andrade (2011) Evolutionary history of Dengue virus type 4: Insights into genotype phylodynamics. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases. ISSN 1567-7257

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Abstract

Dengue virus type four (DENV-4) circulates in tropical and subtropical countries from Asia and the Americas. Despite the importance of dengue virus distribution, little is known about the worldwide viral spread. Following a Bayesian phylogenetic approach we inferred the evolutionary history of 310 isolates sampled from 37 countries during the time period 1956-2008 and the spreading dynamics for genotypes I and II. The region (tropical rainforest biome) comprised by Malaysia-Thailand was the most likely ancestral area from which the serotype has originated and spread. Interestingly, cross-correlation analysis on demographic time series with the Asian sequences showed a statistically significant negative correlation that could be suggestive of competition among genotypes within the same serotype.

Item Type: Article
Creators:
  1. Villabona-Arenas, Christian Julián
  2. Zanotto, Paolo Marinho de Andrade
Journal or Publication Title: Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
Uncontrolled Keywords: dengue;
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine > School of Medicine
Depositing User: Zanaria Saupi Udin
Date Deposited: 25 Feb 2011 09:45
Last Modified: 28 Jul 2011 12:06
URI: http://eprints.um.edu.my/id/eprint/41

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