Zakaria, Sarah Sabrina and Ramanathan, Anand and Ripen, Zakiah Mat and Ghani, Wan Maria Nabillah and Yang, Yi-Hsin and Vincent-Chong, Vui King and Ismail, Siti Mazlipah (2022) Prognostic abilities of pre- and post-treatment inflammatory markers in oral squamous cell carcinoma: Stepwise modelling. Medicina-Lithuania, 58 (10). ISSN 1010-660X, DOI https://doi.org/10.3390/medicina58101426.
Full text not available from this repository.Abstract
Studies examining the importance of inflammatory markers before treatment as prognosticators of OSCC are available, but information on post-therapy inflammatory markers and their prognostic significance is limited. This study aimed to evaluate the prognostic abilities of pre- and post-treatment inflammatory markers in patients with OSCC. Materials and Methods: In this retrospective analysis, information on 151 OSCC patients' socio-demographic, clinico-pathological, recurrence, metastasis, and survival data were gathered from clinical records. A multivariable Cox proportional hazards regression (stepwise model) was conducted to identify the prognostic predictors of OS and DFS. The multivariable models' performances were evaluated using Harrell's concordance statistics. Results: For OS, high pre-treatment LMR (HR 3.06, 95%CI 1.56, 5.99), and high post-treatment PLC (HR 3.35, 95%CI 1.71, 6.54) and PLR (HR 5.26, 95%CI 2.62, 10.58) were indicative of a poor prognosis. For DFS, high pre-treatment SII (HR 2.59, 95%CI 1.50, 4.48) and high post-treatment PLC (HR 1.92, 95%CI 1.11, 3.32) and PLR (HR 3.44, 95%CI 1.98, 5.07) were associated with increased mortality. The fitness of the OS and DFS stepwise Cox regression models were proven with a time-dependent AUC of 0.8787 and 0.8502, respectively. Conclusions: High pre-treatment levels of LMR and SII and high post-treatment levels of PLC and PLR are independent predictors of a poor prognosis for patients with OSCC.
| Item Type: | Article |
|---|---|
| Funders: | Universiti Malaya's impact-oriented interdisciplinary research grant [IIRG027A-2019] [IIRG027B-2019] |
| Uncontrolled Keywords: | Inflammatory markers; Oral squamous cell carcinoma; Prognosis; Overall survival; Disease-free survival |
| Subjects: | R Medicine R Medicine > RK Dentistry |
| Divisions: | Faculty of Dentistry |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 26 Sep 2023 02:15 |
| Last Modified: | 26 Sep 2023 02:15 |
| URI: | http://eprints.um.edu.my/id/eprint/40879 |
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