Arakawa, Kazuharu and Kono, Nobuaki and Malay, Ali D. and Tateishi, Ayaka and Ifuku, Nao and Masunaga, Hiroyasu and Sato, Ryota and Tsuchiya, Kousuke and Ohtoshi, Rintaro and Pedrazzoli, Daniel and Shinohara, Asaka and Ito, Yusuke and Nakamura, Hiroyuki and Tanikawa, Akio and Suzuki, Yuya and Ichikawa, Takeaki and Fujita, Shohei and Fujiwara, Masayuki and Tomita, Masaru and Blamires, Sean J. and Chuah, Jo-Ann and Craig, Hamish and Foong, Choon P. and Greco, Gabriele and Guan, Juan and Holland, Chris and Kaplan, David L. and Sudesh, Kumar and Mandal, Biman B. and Norma-Rashid, Y. and Oktaviani, Nur A. and Preda, Rucsanda C. and Pugno, Nicola M. and Rajkhowa, Rangam and Wang, Xiaoqin and Yazawa, Kenjiro and Zheng, Zhaozhu and Numata, Keiji (2022) 1000 spider silkomes: Linking sequences to silk physical properties. Science Advances, 8 (41). ISSN 2375-2548, DOI https://doi.org/10.1126/sciadv.abo6043.
Full text not available from this repository.Abstract
Spider silks are among the toughest known materials and thus provide models for renewable, biodegradable, and sustainable biopolymers. However, the entirety of their diversity still remains elusive, and silks that exceed the performance limits of industrial fibers are constantly being found. We obtained transcriptome assemblies from 1098 species of spiders to comprehensively catalog silk gene sequences and measured the mechanical, thermal, structural, and hydration properties of the dragline silks of 446 species. The combination of these silk protein genotype-phenotype data revealed essential contributions of multicomponent structures with major ampullate spidroin 1 to 3 paralogs in high-performance dragline silks and numerous amino acid motifs contributing to each of the measured properties. We hope that our global sampling, comprehensive testing, integrated analysis, and open data will provide a solid starting point for future biomaterial designs.
| Item Type: | Article |
|---|---|
| Funders: | ImPACT Program of Council for Science, Technology and Innovation (Cabinet Office, Government of Japan), Yamagata Prefectural Government, Japan Science & Technology Agency (JST) JPMJER1602, Tsuruoka City, Japan |
| Uncontrolled Keywords: | Mechanical property; Evolution; Fibers; Genes |
| Subjects: | Q Science > Q Science (General) |
| Divisions: | Faculty of Science > Institute of Biological Sciences |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 04 Nov 2025 12:48 |
| Last Modified: | 04 Nov 2025 12:48 |
| URI: | http://eprints.um.edu.my/id/eprint/40798 |
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