Jiamsakul, Awachana and Gani, Yasmin and Avihingsanon, Anchalee and Azwa, Iskandar and Chaiwarith, Romanee and Khusuwan, Suwimon and Ross, Jeremy and Law, Matthew and Kiertiburanakul, Sasisopin and Asia-Pacific, IeDEA (2022) Brief report: Mortality after loss to follow-up-a linkage study of people living with HIV in Thailand and Malaysia. Jaids-Journal of Acquired Immune Deficiency Syndromes, 91 (3). pp. 290-295. ISSN 1525-4135, DOI https://doi.org/10.1097/QAI.0000000000003067.
Full text not available from this repository.Abstract
Background: Linkage studies have reported high rates of previously unascertained mortality among people living with HIV (PLHIV) who have been lost to follow-up (LTFU). We assessed survival outcomes among PLHIV who were LTFU in Thailand and Malaysia, through linkages to a national death registry or HIV database. Methods: Data linkages with the national death registry or national HIV database were conducted in 2020 on all PLHIV who met LTFU criteria while enrolled in care at participating HIV clinical sites. LTFU was defined as having no documented clinical contact in the previous year, excluding transfers and deaths. Survival time was analyzed using the Cox regression, stratified by site. Results: Data linkages were performed for 489 PLHIV who had been LTFU at sites in Malaysia (n = 2) and Thailand (n = 4). There were 151 (31%) deaths after being LTFU; the mortality rate was 4.89 per 100 person-years. Risk factors for mortality after being LTFU were older age 41-50 years: hazard ratio (HR) = 1.99, 95% confidence interval (CI): 1.08 to 3.68; and older than 50 years: HR = 4.93, 95% CI: 2.63 to 9.22; vs. age 30 years or younger]; receiving NRTI + PI (HR = 1.87, 95% CI: 1.22 to 2.85 vs. NRTI + NNRTI); positive hepatitis C antibody (HR = 2.25, 95% CI: 1.40 to 3.62); and having previous AIDS illness (HR = 1.45, 95% CI: 1.03 to 2.05). An improved survival was seen with a higher CD4 count (CD4 351-500 cells/mu L: HR = 0.40, 95%CI: 0.21-0.76; and CD4 >500 cells/mu L: HR = 0.43, 95%CI: 0.25-0.75; vs. CD4 <= 200 cells/mu L). Conclusions: Almost one-third of PLHIV who were LTFU in this cohort had died while out of care, emphasizing the importance of efforts to reengage PLHIV after they have been LTFU and ensure they have access to ongoing ART.
| Item Type: | Article |
|---|---|
| Funders: | United States Department of Health & Human Services, National Institutes of Health (NIH) - USA, NIH National Institute of Allergy & Infectious Diseases (NIAID), United States Department of Health & Human Services, NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD), United States Department of Health & Human Services, NIH National Cancer Institute (NCI), United States Department of Health & Human Services, NIH National Institute of Mental Health (NIMH), NIH National Institute on Alcohol Abuse & Alcoholism (NIAAA), National Institutes of Health (NIH) - USA, NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK), United States Department of Health & Human Services, Fogarty International Center, as part of the International Epidemiology, Databases to Evaluate AIDS (IeDEA) U01AI069907, Australian Government, Department of Health & Ageing, Faculty of Medicine, UNSW Sydney |
| Uncontrolled Keywords: | Loss to follow-up; Asia; Survival; Linkage; Trace |
| Subjects: | H Social Sciences > HB Economic Theory R Medicine > R Medicine (General) R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine |
| Divisions: | Faculty of Medicine > Medicine Department |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 15 Oct 2023 14:33 |
| Last Modified: | 15 Oct 2023 14:34 |
| URI: | http://eprints.um.edu.my/id/eprint/40741 |
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