Quality of chloroquine tablets available in Africa

Sawadogo, C.W.; Al-Kamarany, M.A.; Al-Mekhlafi, H.M.; Elkarbane, M.; Al-Adhroey, A.H.; Cherrah, Y.; Bouklouze, A. (2011) Quality of chloroquine tablets available in Africa. Annals of Tropical Medicine and Parasitology, 105 (6). pp. 447-453. ISSN 0003-4983

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Abstract

Malaria is the biggest killer of African children, yet it is cheaply preventable and curable with insecticides spraying, impregnated bednets and effective drugs. This study aimed to evaluate the quality of Chloroquine (CQ) tablets available in selected African countries. Twenty-six samples of antimalarial CQ tablet of 100, 150 and 250 mg were collected from 12 African countries and evaluated for their quality in the Drugs Quality Control Laboratory of Rabat, Morocco. The identification and dosage of active pharmaceutical ingredients in the tablets, dissolution rate, hardness and the friability of CQ tablets were performed according to the United States Pharmacopeia (USP) and European Pharmacopoeia (Eur.Ph.) recommended methods. The results showed that 7.7 of the sampled CQ tablets available in Burkina Faso were of low quality. Failure in dissolution profile was found in 50 of CQ tablets sampled from Benin, Burkina Faso, Comoros Union, Mali and Senegal. The findings showed poor quality of CQ tablets available in the African market. This problem may affect the efforts to control malaria in Africa. Efficient regulatory systems of drugs quality control should be implemented.

Item Type: Article
Creators:
  1. Sawadogo, C.W.
  2. Al-Kamarany, M.A.
  3. Al-Mekhlafi, H.M.
  4. Elkarbane, M.
  5. Al-Adhroey, A.H.
  6. Cherrah, Y.
  7. Bouklouze, A.
Journal or Publication Title: Annals of Tropical Medicine and Parasitology
Additional Information: Sawadogo, C. W. Al-Kamarany, M. Amood Al-Mekhlafi, H. M. Elkarbane, M. Al-Adhroey, A. H. Cherrah, Y. Bouklouze, A.
Subjects: R Medicine
Divisions: UNSPECIFIED
Depositing User: Mr. Mohammed Salim Abd Rahman
Date Deposited: 06 Dec 2012 16:23
Last Modified: 06 Dec 2012 16:23
URI: http://eprints.um.edu.my/id/eprint/4073

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