Ponnampalavanar, Sasheela Sri La Sri and Karunakaran, Rina and Vellasamy, Kumutha Malar and Jabar, Kartini Abdul and Teh, Cindy Shuan Ju (2022) Characterisation of Non-Carbapenemase-Producing Carbapenem-Resistant Klebsiella pneumoniae based on their clinical and molecular profile in Malaysia. Antibiotics-Basel, 11 (11). ISSN 2079-6382, DOI https://doi.org/10.3390/antibiotics11111670.
Full text not available from this repository.Abstract
Non-carbapenemase-producing carbapenem-resistant Klebsiella pneumoniae (NC-CRKP) confers carbapenem resistance through a combination of chromosomal mutations and acquired non-carbapenemase resistance mechanisms. In this study, we aimed to evaluate the clinical and molecular profiles of NC-CRKP isolated from patients in a tertiary teaching hospital in Malaysia from January 2013 to October 2019. During the study period, 54 NC-CRKP-infected/colonised patients' isolates were obtained. Clinical parameters were assessed in 52 patients. The all-cause in-hospital mortality rate among NC-CRKP patients was 46.2% (24/52). Twenty-three (44.2%) patients were infected, while others were colonised. Based on the Charlson Comorbidity Index (CCI) score, 92.3% (48/52) of the infected/colonised patients had a score of >= 1. Resistance genes found among the 54 NC-CRKP isolates were bla(TEM), bla(SHV), bla(CTX-M), bla(OXA), and bla(DHA). Porin loss was detected in 25/54 (46.3%) strains. None of the isolated strains conferred carbapenem resistance through the efflux pumps system. In conclusion, only 25/54 (46.3%) NC-CRKP conferred carbapenem resistance through a combination of porin loss and the acquisition of non-carbapenemase resistance mechanisms. The carbapenem resistance mechanisms for the remaining strains (53.7%) should be further investigated as rapid identification and distinction of the NC-CRKP mechanisms enable optimal treatment and infection control efforts.
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Higher Education (Malaysia), Fundamental Research Grant Scheme (FRGS), FRGS/1/2018/SKK11/UM/02/4, FP013-2018A, IF066-2020 |
| Uncontrolled Keywords: | All-cause in-hospital mortality; Charlson Comorbidity Index (CCI); Efflux pump; Non-carbapenemase-producing carbapenem-resistant Klebsiella pneumoniae; Porin loss; Resistance genes |
| Subjects: | Q Science > QR Microbiology |
| Divisions: | Faculty of Medicine > Medicine Department |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 15 Oct 2023 16:09 |
| Last Modified: | 15 Oct 2023 16:09 |
| URI: | http://eprints.um.edu.my/id/eprint/40605 |
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