Acute oral toxicity and brine shrimp lethality of elaeis guineensis Jacq., (Oil Palm Leaf) methanol extract

Syahmi, A.R.M.; Vijayarathna, S.; Sasidharan, S.; Latha, L.Y.; Kwan, Y.P.; Lau, Y.L.; Shin, L.N.; Chen, Y. (2010) Acute oral toxicity and brine shrimp lethality of elaeis guineensis Jacq., (Oil Palm Leaf) methanol extract. Molecules, 15 (11). pp. 8111-8121. ISSN 1420-3049

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      Abstract

      Elaeis guineensis (Arecaceae) is widely used in West African traditional medicine for treating various ailments. An evaluation on the toxicity of extracts of this plant is crucial to support the therapeutic claims. The acute oral toxicity and brine shrimp lethality of a methanolic extract of this plant was tested. Oral administration of crude extract at the highest dose of 5,000 mg/kg resulted in no mortalities or evidence of adverse effects, implying that E. guineensis is nontoxic. Normal behavioral pattern, clinical signs and histology of vital organs confirm this evidence. The E. guineensis extracts screened for toxicity against brine shrimp had 50 lethal concentration (LC(50)) values of more than 1.0 mg/mL (9.00 and 3.87 mg/mL, at 6 and 24 h, respectively), confirming that the extract was not toxic. Maximum mortalities occurred at 100 mg/mL concentration while the least mortalities happened to be at 0.195 mg/mL concentration. The results of both tests confirm that E. guineensis is nontoxic and hence safe for commercial utilization.

      Item Type: Article
      Creators:
      1. Syahmi, A.R.M.
      2. Vijayarathna, S.
      3. Sasidharan, S.
      4. Latha, L.Y.
      5. Kwan, Y.P.
      6. Lau, Y.L.
      7. Shin, L.N.
      8. Chen, Y.
      Journal or Publication Title: Molecules
      Additional Information: ISI Document Delivery No.: 684VR Times Cited: 3 Cited Reference Count: 15 Cited References: ASANTEDUAH K, 2002, PUBLIC HLTH RISK ASS, V6 Bellini MF, 2008, GENET MOL BIOL, V31, P122 Bodeker G, 2007, TRADITIONAL COMPLEME HUMBER JM, 2002, JAMA-J AM MED ASSOC, V288, P1655, DOI 10.1001/jama.288.13.1655 IRVIN TT, 1985, ARCH EMERG MED, V2, P3 ISLAM MK, 2009, J SCI RES, V1, P399 Joshi CS, 2007, J HEALTH SCI, V53, P245, DOI 10.1248/jhs.53.245 Mcmanus J.G.A., 1984, STAINING METHODS HIS MEYER BN, 1982, PLANTA MED, V45, P31, DOI 10.1055/s-2007-971236 Moshi MJ, 2007, AFR J TRADIT COMPLEM, V4, P219 Roopashree T. S., 2009, The Thai Journal of Pharmaceutical Sciences, V33, P74 Sasidharan S, 2008, PHARM BIOL, V46, P413, DOI 10.1080/13880200802055867 WALUM E, 1995, ALTERNATIVE METHODS, V11, P275 2001, OECD GUIDELINES ACUT 2001, OECD GUIDELINES TEST Syahmi, Abdul Rani Muhamad Vijayarathna, Soundararajan Sasidharan, Sreenivasan Latha, Lachimanan Yoga Kwan, Yuet Ping Lau, Yee Ling Shin, Lai Ngit Chen, Yeng Mdpi ag Basel
      Uncontrolled Keywords: Elaeis guineensis methanol extract acute oral toxicity brine shrimp lethality assay
      Subjects: R Medicine > RK Dentistry
      Divisions: Faculty of Dentistry
      Depositing User: Ms Nursyafiqah Abd Malek
      Date Deposited: 05 Dec 2012 11:57
      Last Modified: 05 Dec 2012 11:57
      URI: http://eprints.um.edu.my/id/eprint/4048

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