Hadi, Muhammad Fahmi Rizal Abdul and Abdullah, Arifah Nazirah and Hashikin, Nurul Ab Aziz and Ying, Chee Keat and Yeong, Chai Hong and Yoon, Tiem Leong and Ng, Kwan Hoong (2022) Utilizing 3D Slicer to incorporate tomographic images into GATE Monte Carlo simulation for personalized dosimetry in yttrium-90 radioembolization. Medical Physics, 49 (12). pp. 7742-7753. ISSN 2473-4209, DOI https://doi.org/10.1002/mp.15980.
Full text not available from this repository.Abstract
Purpose Monte Carlo (MC) simulation is an important technique that can help design advanced and challenging experimental setups. GATE (Geant4 application for tomographic emission) is a useful simulation toolkit for applications in nuclear medicine. Transarterial radioembolization is a treatment for liver cancer, where microspheres embedded with yttrium-90 (Y-90) are administered intra-arterially to the tumor. Personalized dosimetry for this treatment may provide higher dosimetry accuracy compared to the conventional partition model (PM) calculation. However, incorporation of three-dimensional tomographic input data into MC simulation is an intricate process. In this article, 3D Slicer, free and open-source software, was utilized for the incorporation of patient tomographic images into GATE to demonstrate the feasibility of personalized dosimetry in hepatic radioembolization with Y-90. Methods In this article, the steps involved in importing, segmenting, and registering tomographic images using 3D Slicer were thoroughly described, before importing them into GATE for MC simulation. The absorbed doses estimated using GATE were then compared with that of PM. SlicerRT, a 3D Slicer extension, was then used to visualize the isodose from the MC simulation. Results A workflow diagram consisting of all the steps taken in the utilization of 3D Slicer for personalized dosimetry in Y-90 radioembolization has been presented in this article. In comparison to the MC simulation, the absorbed doses to the tumor and normal liver were overestimated by PM by 105.55% and 20.23%, respectively, whereas for lungs, the absorbed dose estimated by PM was underestimated by 25.32%. These values were supported by the isodose distribution obtained via SlicerRT, suggesting the presence of beta particles outside the volumes of interest. These findings demonstrate the importance of personalized dosimetry for a more accurate absorbed dose estimation compared to PM. Conclusion The methodology provided in this study can assist users (especially students or researchers who are new to MC simulation) in navigating intricate steps required in the importation of tomographic data for MC simulation. These steps can also be utilized for other radiation therapy related applications, not necessarily limited to internal dosimetry.
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Education, Malaysia [Grant No: FRGS/1/2019/STG02/USM/02/2] |
| Uncontrolled Keywords: | 3D Slicer; GATE; Geant4; Radioembolization; Yttrium-90 |
| Subjects: | Q Science > QC Physics R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
| Divisions: | Faculty of Medicine > Biomedical Imaging Department |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 15 Jul 2024 03:49 |
| Last Modified: | 15 Jul 2024 08:18 |
| URI: | http://eprints.um.edu.my/id/eprint/40411 |
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