Ong, Leong Tung and Fan, Si Wei David (2022) The association between congenital cytomegalovirus infection and cerebral palsy: A systematic review and meta-analysis. Journal of Paediatrics and Child Health, 58 (12). pp. 2156-2162. ISSN 1034-4810, DOI https://doi.org/10.1111/jpc.16244.
Full text not available from this repository.Abstract
Cytomegalovirus (CMV) is the most common cause of congenital infection, affecting 1% of all live births. Intrauterine infection such as CMV infection is a risk factor for developing cerebral palsy. This study aims to investigate the association between congenital CMV infection and the development of cerebral palsy. A systematic literature search was conducted in PubMed, Web of Science and Ovid SP to identify relevant studies. The quality of studies was assessed using the Newcastle-Ottawa Scale. The random-effect model was used to calculate the pooled prevalence. The generic inverse variance method was used for statistical analysis. A total of 12 studies were included in this systematic review and meta-analysis. The overall pooled prevalence of cerebral palsy among patients diagnosed with congenital CMV infection was 26% (95% confidence interval (CI), 13-40%). The overall pooled prevalence of congenital CMV infection among patients with cerebral palsy was 10.9% (95% CI, 5-16%). Congenital CMV infection was significantly associated with the development of cerebral palsy in children. Routine follow-ups should be offered to screen for cerebral palsy.
| Item Type: | Article |
|---|---|
| Funders: | None |
| Uncontrolled Keywords: | Cerebral palsy; Congenital cytomegalovirus; Infection; Outcome |
| Subjects: | R Medicine > RJ Pediatrics |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 22 Nov 2023 06:38 |
| Last Modified: | 22 Nov 2023 06:38 |
| URI: | http://eprints.um.edu.my/id/eprint/40386 |
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