Cheong, Heng Choon and Cheok, Yi Ying and Chan, Yee Teng and Sulaiman, Sofiah and Looi, Chung Yeng and Alshanon, Ahmed F. and Hassan, Jamiyah and Abu Bakar, Sazaly and Wong, Won Fen (2022) Zika virus vaccine: The current state of affairs and challenges posed by antibody-dependent enhancement reaction. Viral Immunology, 35 (9). pp. 586-596. ISSN 0882-8245, DOI https://doi.org/10.1089/vim.2022.0082.
Full text not available from this repository.Abstract
Infection caused by the Zika virus (ZIKV) can lead to serious neurological complications such as microcephaly in neonates. At present, no approved ZIKV vaccine is available, but few vaccine candidates are undergoing clinical trial. One major challenge faced is antibody-dependent enhancement (ADE) reaction that may provoke severe outcome in subsequent infection by ZIKV or other flaviviruses. Thus, more efforts should be dedicated to understanding ADE in designing a safe and effective vaccine to minimize the consequence of the potentially fatal infection's complications and to tackle potential ZIKV reemergence. This review discusses different types of ZIKV vaccine candidates that are currently underway in various stages of preclinical and clinical evaluations.
| Item Type: | Article |
|---|---|
| Funders: | None |
| Uncontrolled Keywords: | Antibody-dependent enhancement; Humoral immunity; Pathogenesis; Vaccines; Zika virus |
| Subjects: | Q Science > QR Microbiology R Medicine > RA Public aspects of medicine |
| Divisions: | Faculty of Medicine Deputy Vice Chancellor (Research & Innovation) Office > Tropical Infectious Diseases Research and Education Centre |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 17 Oct 2023 03:36 |
| Last Modified: | 03 Dec 2023 02:24 |
| URI: | http://eprints.um.edu.my/id/eprint/40374 |
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