Different altered stage correlative expression of high abundance acute-phase proteins in sera of patients with epithelial ovarian carcinoma

Chen, Yeng and Lim, Boon Kiong and Hashim, Onn Haji (2009) Different altered stage correlative expression of high abundance acute-phase proteins in sera of patients with epithelial ovarian carcinoma. Journal of Hematology & Oncology, 2. p. 37. ISSN 1756-8722, DOI https://doi.org/10.1186/1756-8722-2-37.

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Official URL: https://doi.org/10.1186/1756-8722-2-37

Abstract

Background: The general enhanced expression of alpha(1)-antichymotrypsin (ACT), clusterin (CLU), alpha(1)-antitrypsin (AAT), haptoglobin beta-chain (HAP), and leucine rich glycoprotein (LRG) in the sera of patients with epithelial ovarian carcinoma (EOCa) was recently reported. In the present study, we compared the expression of the serum acute-phase proteins (APPs) in the patients according to their stages of cancer. Results: Different altered stage correlative expression of the high abundance serum APPs was demonstrated in sera of the patients studied. While the expression of ACT, HAP and AAT appeared to demonstrate positive correlation with the three initial stages of the cancer, inverse correlation was apparently detected in the expression of LRG and CLU. For patients who were diagnosed with stage IV of the cancer, expression of the serum APPs did not conform to the altered progression changes. Conclusion: Our results highlight the potential prognostic significance of selective high abundance serum APPs in patients with EOCa.

Item Type: Article
Funders: UNSPECIFIED
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Uncontrolled Keywords: Epithelial Ovarian Carcinoma; Endometrial Adenocarcinoma; High Abundance Protein; Squamous Cell Cervical Carcinoma; Release Version
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms Nursyafiqah Abd Malek
Date Deposited: 05 Dec 2012 03:50
Last Modified: 13 Jul 2020 06:59
URI: http://eprints.um.edu.my/id/eprint/4034

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