Ahn, Myung-Ju and Mendoza, Marvin Jonne L. and Pavlakis, Nick and Kato, Terufumi and Soo, Ross A. and Kim, Dong-Wan and Liam, Chong Kin and Hsia, Te-Chun and Lee, Chee Khoon and Reungwetwattana, Thanyanan and Geater, Sarayut and Chan, Oscar Siu Hong and Prasongsook, Naiyarat and Solomon, Benjamin J. and Nguyen, Thi Thai Hoa and Kozuki, Toshiyuki and Yang, James Chih-Hsin and Wu, Yi-Long and Kam, Tony Shu and Tan, Daniel Shao-Weng and Yatabe, Yasushi (2022) Asian Thoracic Oncology Research Group (ATORG) expert consensus statement on MET alterations in NSCLC: Diagnostic and therapeutic considerations. CLINICAL LUNG CANCER, 23 (8). pp. 670-685. ISSN 1938-0690, DOI https://doi.org/10.1016/j.cllc.2022.07.012.
Full text not available from this repository.Abstract
Non-small cell lung cancer (NSCLC) is a heterogeneous disease, with many oncogenic driver mutations, including de novo mutations in the Mesenchymal Epithelial Transition ( MET ) gene (specifically in Exon 14 ex14]), that lead to tumourigenesis. Acquired alterations in the MET gene, specifically MET amplification is also associated with the development of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) resistance in patients with EGFR-mutant NSCLC. Although MET has become an actionable biomarker with the availability of MET-specific inhibitors in selected countries, there is differential accessibility to diagnostic platforms and targeted therapies across countries in Asia-Pacific (APAC). The Asian Thoracic Oncology Research Group (ATORG), an interdisciplinary group of experts from Australia, Hong Kong, Japan, Korea, Mainland China, Malaysia, the Philippines, Singapore, Taiwan, Thailand and Vietnam, discussed testing for MET alterations and considerations for using MET-specific inhibitors at a consensus meeting in January 2022, and in subsequent offline consultation. Consensus recommendations are provided by the ATORG group to address the unmet need for standardised approaches to diagnosing MET alterations in NSCLC and for using these therapies. MET inhibitors may be considered for first-line or second or subsequent lines of treatment for patients with advanced and metastatic NSCLC harbouring MET ex14 skipping mutations; MET ex14 testing is preferred within multi-gene panels for detecting targetable driver mutations in NSCLC. For patients with EGFR-mutant NSCLC and MET amplification leading to EGFR TKI resistance, enrolment in combination trials of EGFR TKIs and MET inhibitors is encouraged. Clinical Lung Cancer, Vol. 23, No. 8, 670-685 (c) 2022 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research (KAKENHI) [20H03461] |
| Uncontrolled Keywords: | Asia-Pacific; Lung cancer; MET inhibitors; MET exon 14 mutation; MET amplification in EGFR TKI resistance |
| Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
| Divisions: | Faculty of Medicine > Medicine Department |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 09 Jul 2024 06:52 |
| Last Modified: | 09 Jul 2024 06:52 |
| URI: | http://eprints.um.edu.my/id/eprint/40331 |
Actions (login required)
 |
View Item |
