Padmanabhan, Varun Prasath and Sivashanmugam, Pugalmani and Kulandaivelu, Ravichandran and Sagadevan, Suresh and Sridevi, Balu and Govindasamy, Rajakumar and Thiruvengadam, Muthu (2022) Biosynthesised silver nanoparticles loading onto biphasic calcium phosphate for antibacterial and bone tissue engineering applications. Antibiotics-Basel, 11 (12). ISSN 2079-6382, DOI https://doi.org/10.3390/antibiotics11121780.
Full text not available from this repository.Abstract
Biphasic calcium phosphate (BCP) serves as one of the substitutes for bone as it consists of an intimate mixture of beta-tricalcium phosphate (beta-TCP) and hydroxyapatite (HAP) in different ratios. BCP, because of its inbuilt properties such as osteoconductivity, biocompatibility, and biostability in several clinical models serves as a bone substituent for orthopedic applications. Therefore, the present study aimed to assess the effectiveness of silver (Ag) nanoparticles (NPs) combined with BCP composites for the orthopedic sector of bone tissue regeneration and growth. In this regard, we first synthesized Ag-BCP microclusters by the double-emulsion method and then characterized the composite for various physicochemical properties, including the crystallinity and crystal structure, bonding and functionality, porosity, morphology, surface charges, topography, and thermal stability. In addition, the antibacterial activity of Ag-BCP was tested against gram-positive and gram-negative microorganisms such as Staphylococcus aureus, Candida albicans, and Escherichia coli. Finally, the cytocompatibility of Ag-BCP was confirmed against the fibroblast cells in vitro.
| Item Type: | Article |
|---|---|
| Funders: | Council of Scientific & Industrial Research (CSIR) - India (Grant No: 09/115(0793)/2020 EMR-I) |
| Uncontrolled Keywords: | Biphasic calcium phosphate; Ag nanoparticles; Antibacterial activity; Hydroxyapatite; Beta-tricalcium phosphate; MTT assay |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Nanotechnology & Catalysis Research Centre |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 23 Nov 2023 04:29 |
| Last Modified: | 23 Nov 2023 04:29 |
| URI: | http://eprints.um.edu.my/id/eprint/40301 |
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