Kherul Anuwar, Ainol Haniza and Saub, Roslan and Safii, Syarida Hasnur and Ab Murat, Norintan and Taib, Mohd Syukri Mohd and Mamikutty, Rokiah and Ng, Chiu Wan (2022) Systemic antibiotics as an adjunct to subgingival debridement: A network meta-analysis. Antibiotics-Basel, 11 (12). ISSN 2079-6382, DOI https://doi.org/10.3390/antibiotics11121716.
Full text not available from this repository.Abstract
This review aimed to evaluate the effectiveness of systemic antibiotics as adjunctive treatment to subgingival debridement in patients with periodontitis. Randomized controlled trials were included that assessed the effectiveness of systemic antibiotics in improving periodontal status, indicated by clinical attachment gain level, probable pocket depth reduction, and bleeding on probing reduction of patients with any form of periodontitis at any follow-up time. Network meta-analyses with a frequentist model using random effects was employed to synthesize the data. The relative effects were reported as mean difference with a 95% confidence interval. Subsequently, all treatments were ranked based on their P-scores. A total of 30 randomized controlled trials were included in this network meta-analyses. Minimally important clinical differences were observed following the adjunctive use of satranidazole, metronidazole, and clindamycin for clinical attachment gain level and probable pocket depth reduction. For bleeding on probing reduction, minimally important clinical differences were observed following the adjunctive use of metronidazole and a combination of amoxycillin and metronidazole. However, the network estimates were supported by evidence with certainty ranging from very low to high. Therefore, the findings of this network meta-analyses should be interpreted with caution. Moreover, the use of these antibiotics adjunct to subgingival debridement should be weighed against possible harm to avoid overuse and inappropriate use of these antibiotics in patients with periodontitis.
| Item Type: | Article |
|---|---|
| Funders: | None |
| Uncontrolled Keywords: | Evidence-based dentistry; Network meta-analysis; Antibacterial agents; Systemic antibiotics; Adjunct; Periodontal debridement; Subgingival debridement; Periodontitis |
| Subjects: | R Medicine > RK Dentistry > Preventive dentistr R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Faculty of Dentistry Faculty of Medicine > Social & Preventive Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 24 Nov 2023 04:24 |
| Last Modified: | 24 Nov 2023 04:24 |
| URI: | http://eprints.um.edu.my/id/eprint/40270 |
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