Khoo, Su Pei and Muhammad Ridzuan Tan, Nor Adriana and Rajasuriar, Reena and Nasir, Nazrila Hairizan and Gravitt, Patti and Ng, Chiu Wan and Woo, Yin Ling (2022) Changes in genital Human Papillomavirus (HPV) prevalence among urban females a decade after the Malaysian HPV vaccination program. PLoS ONE, 17 (12). ISSN 1932-6203, DOI https://doi.org/10.1371/journal.pone.0278477.
Full text not available from this repository.Abstract
To increase the coverage of HPV vaccination, Malaysia implemented a national school-based vaccination program for all 13-year-old girls in 2010. Two years later, a clinic-based catch-up program was started for 16 to 21-year-old girls. We assessed the prevalence of a range of HPV genotypes, among a sample of urban women within the age groups of 18-24 and 35-45 years in 2019-2020, a decade into the national vaccination program. The HPV prevalence was then compared to that reported in an unvaccinated population in 2013-2015. We sampled a total of 1134 participants, comprising of 277 women aged 18-24 years and 857 women aged 35-45 years, from several urban clinics in the state of Selangor. Participants provided a self-acquired vaginal sample for HPV genotyping. Comprehensive sociodemographic and vaccination history were collected. The HPV vaccination coverage among women in the younger age group increased from 9.3% in 2013-2015 to 75.5% in 2019-2020. The prevalence of vaccine-targeted HPV16/18 decreased 91% (CI: 14.5%-99.0%) among the younger women, from 4.0% in 2013-2015 to 0.4% in 2019-2020. There was also an 87% (CI: 27.5%-97.5%) reduction in HPV6/11/16/18. There was no difference in the prevalence of non-vaccine targeted HPV genotypes among younger women. The HPV prevalence among older women, for both vaccine targeted and non-vaccine targeted genotypes in 2019-2020, did not differ from 2013-2015. The observed decline in prevalence of vaccine-targeted HPV genotype among younger women a decade after the national HPV vaccination program is an early indication of its effectiveness in reducing the burden of cervical cancer.
| Item Type: | Article |
|---|---|
| Funders: | Investigator Initiated Studies Program of MSD |
| Uncontrolled Keywords: | Invasive cervical-cancer; Intraepithelial Neoplasia; Infection; Women |
| Subjects: | Q Science > QR Microbiology |
| Divisions: | Faculty of Medicine > Obstetrics & Gynaecology Department Faculty of Medicine > Social & Preventive Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 16 Oct 2023 04:03 |
| Last Modified: | 24 Oct 2023 03:06 |
| URI: | http://eprints.um.edu.my/id/eprint/40237 |
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