Zinc accelerates Dengue Virus Type 2-Induced Aapoptosis in Vero Cells

Shafee, N.; AbuBakar, S. (2002) Zinc accelerates Dengue Virus Type 2-Induced Aapoptosis in Vero Cells. Febs Letters, 524 (1-3). pp. 20-24. ISSN 0014-5793

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    Dengue virus type 2 (DENV-2) infection induced apoptotic cellular DNA fragmentation in Vero cells within 8 days of infection. The addition of high concentrations of extracellular Zn2+ but not Ca2+, Mg2+ or Mn2+ to the cell culture medium hastened the detection of apoptosis to within 4 h after infection. No apoptotic cellular DNA fragmentation was detected in the cell culture treated with Zn2+ alone or infected with heat- or ultraviolet light-inactivated DENV-2 in the presence of Zn2+. These results suggest that (i) apoptosis is induced in African green monkey kidney cells infected with live DENV-2 and (ii) the addition of high extracellular Zn2+ accelerates detection of apoptosis in the DENV-2-infected cells. (C) 2002 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.

    Item Type: Article
    1. Shafee, N.
    2. AbuBakar, S.(Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, MALAYSIA)
    Journal or Publication Title: Febs Letters
    Additional Information: Shafee, Norazizah AbuBakar, Sazaly eng Research Support, Non-U.S. Gov't Netherlands 2002/07/24 10:00 FEBS Lett. 2002 Jul 31;524(1-3):20-4.
    Uncontrolled Keywords: Animals Apoptosis/*drug effects/*physiology Cercopithecus aethiops Dengue Virus/*physiology In Situ Nick-End Labeling Vero Cells Zinc/*pharmacology
    Subjects: R Medicine
    Divisions: Faculty of Medicine
    Depositing User: miss munirah saadom
    Date Deposited: 05 Dec 2012 11:42
    Last Modified: 07 Nov 2017 16:06
    URI: http://eprints.um.edu.my/id/eprint/4007

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