Phylogenetic investigation of Dengue Virus Type 2 isolated in Malaysia

Chee, H.Y. and AbuBakar, Sazaly (2003) Phylogenetic investigation of Dengue Virus Type 2 isolated in Malaysia. Dengue Bulletin, 27. pp. 100-107. ISSN 1020-895X

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Abstract

Dengue virus type-2 (DEN-2) has been isolated in Malaysia for more than three decades. The virus caused two major outbreaks in the early 1990s and late 1990s. Phylogenetic analyses performed using available E/NS1 junction sequences identified two DEN-2 genotypes: DEN-2 Asian 1 and DEN-2 Cosmopolitan. DEN-2 Cosmopolitan/Malaysia is the predominant genotype comprising more than 80 of the total isolates. Two different clades of DEN-2 Cosmopolitan/Malaysia genotype were identified. Clade I consisted of mainly the older isolates, whereas Clade II consisted of the more recent isolates, including that responsible for both the major DEN-2 outbreaks. Two different strains of DEN- 2 Cosmopolitan/Malaysia genotype were involved in the outbreaks, yet both strains appeared to share a common ancestral lineage with isolates from the early 1970s. Isolates from the late 1990s showed higher sequence similarities to the late-1960s isolates than the early-1990s isolates. These findings raised the possibility that the different DEN-2 strains noted over the last three decades in Malaysia might have evolved from a pre existing DEN-2 gene pool.

Item Type: Article
Additional Information: Department of Medical Microbiology, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA
Uncontrolled Keywords: Dengue, genotypes, outbreak, phylogenetic, Malaysia
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: miss munirah saadom
Date Deposited: 05 Dec 2012 03:56
Last Modified: 13 Feb 2019 08:02
URI: http://eprints.um.edu.my/id/eprint/4005

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