Nipah virus: phylogeny and replication

Chang, L.Y.; AbuBakar, S. (2009) Nipah virus: phylogeny and replication. Neurology Asia, 14 (1). pp. 63-66. ISSN 1823-6138

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Abstract

Phylogenetic analysis of Nipah virus isolates from Malaysia, Bangladesh and Cambodia suggested the presence of at least two different clusters of NiV strains. Based on the major glycoprotein ( G) gene, the Nipah virus-Tambun isolate clustered with Nipah virus isolates from Cambodia and Bangladesh, whereas the remaining isolates from Malaysia clustered in a separate cluster. Sequence heterogeneity among the Nipah virus isolates from Malaysia was noted but the overall genomic sequence divergence value was small, suggesting a possible recent introduction of the virus. Nipah virus replicated well in porcine stable kidney cells and human lung fibroblast cells. Human monocytes, on the other hand were infected with Nipah virus but the cells did not support productive infection. Similarly, infection of human neuronal cells did not result in release of high infectious virus yield. The monocytes can serve to disseminate Nipah virus from site of infection including across the blood-brain barrier. And in the brain, Nipah virus is probably spread through cell-to-cell spread mechanism.

Item Type: Article
Creators:
  1. Chang, L.Y.
  2. AbuBakar, S.(Department of Medical Microbiology, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA)
Journal or Publication Title: Neurology Asia
Additional Information: Times Cited: 1 Nipah Virus Colloquium Oct 21-22, 2008 Univ Malaya, Kuala Lumpur, MALAYSIA
Uncontrolled Keywords: Molecular Characterization; Henipavirus Infection; Peninsular Malaysia; Flying-Foxes; Pig-Farmers; Fruit Bats; Encephalitis; India; Paramyxovirus; Siliguri
Subjects: R Medicine
Divisions: UNSPECIFIED
Depositing User: Mr. Mohammed Salim Abd Rahman
Date Deposited: 12 Nov 2012 10:09
Last Modified: 12 Nov 2012 10:09
URI: http://eprints.um.edu.my/id/eprint/3980

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