LNCaP prostate cancer cells are insensitive to zinc-induced senescence

Wong, P.F.; AbuBakar, S. (2008) LNCaP prostate cancer cells are insensitive to zinc-induced senescence. Journal of Trace Elements in Medicine and Biology, 22 (3). pp. 242-247. ISSN 0946-672X

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    Abstract

    Prostate cancer is an age-related disease that is linked to the inability of prostate cells to accumulate zinc following transformation. It is shown in the present study the the basal percentage of normal prostate cells expressing senescence-associated beta-galactosidase (SA-beta-gal) is higher than that of the cancer cells. In the presence of high zinc in the cell culture medium, the percentage of normal prostate cells expressing the SA-beta-gal increased but not that of the cancer cells. Increased intracellular zinc occurs in the prostate cancer cells treated with supraphysiologic concentration of zinc but it does not induce senescence or decrease the telomerase activities in these cells. Senescence, however, occurred when the prostate cancer cells DNA is damaged by irradiation. These findings suggest that prostate cancer cells are insensitive to the senescence-inducing effects of zinc but the cancer cells retain the capacity to undergo senescence through other pathways. (c) 2008 Elsevier GmbH. All rights reserved.

    Item Type: Article
    Creators:
    1. Wong, P.F.
    2. AbuBakar, S.(Department of Medical Microbiology, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA)
    Journal or Publication Title: Journal of Trace Elements in Medicine and Biology
    Additional Information: Wong, Pooi-Fong Abubakar, Sazaly eng Research Support, Non-U.S. Gov't Germany GMS 2008/08/30 09:00 J Trace Elem Med Biol. 2008;22(3):242-7. Epub 2008 Jun 26.
    Uncontrolled Keywords: Cell Aging/*drug effects Cell Line, Tumor Cell Shape/drug effects Health Humans Male Prostate/drug effects Prostatic Neoplasms/enzymology/*pathology Substrate Specificity Telomerase/metabolism Zinc/*pharmacology
    Subjects: R Medicine
    Divisions: Faculty of Medicine
    Depositing User: Mr Jenal S
    Date Deposited: 27 Nov 2012 10:14
    Last Modified: 27 Nov 2012 10:14
    URI: http://eprints.um.edu.my/id/eprint/3970

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