Mosiun, J. A. and See, Mee-Hoong and Teoh, Li-Ying and Danaee, Mahmoud and Lai, Lee-Lee and Ng, Char-Hong and Yip, Cheng-Har and Teh, Mei-Sze and Mohd Taib, Nur Aishah and Bustam, Anita and Malik, Rozita Abdul and Saad, Marniza and Jamaris, Suniza and Ung, Ngie-Min (2023) Comparison of clinical outcomes between low- and high-risk groups of early breast cancer patients treated with intraoperative radiotherapy in addition to external beam radiation: A multi-centre prospective study. World Journal of Surgery, 47 (1). pp. 201-208. ISSN 0364-2313, DOI https://doi.org/10.1007/s00268-022-06753-0.
Full text not available from this repository.Abstract
Background There is a paucity of data on the use of intraoperative radiotherapy (IORT) with low-energy X-rays in Malaysian women with early breast cancer. The aim of this study is to evaluate the clinical, cosmetic, and patient-reported outcomes in low- and high-risk early breast cancer patients treated with breast conserving surgery (BCS) and IORT. Methodology Patients suitable for BCS who were treated with IORT between January 2016 and June 2019 from three centres were analysed. They were divided into low-risk and high-risk groups based on the risk of recurrence according to the TARGeted Intraoperative radioTherapy (TARGIT) A and B study criteria. Outcomes of interest included local recurrence, wound complications, and radiation toxicity, with a subset analysed for cosmetic and patient-reported outcomes. Results Within a median follow-up of 31 months, there were 104 and 211 patients in the low- and high-risk groups, respectively. No significant difference was observed in local recurrence rates (low-risk, 1.0% vs. high-risk, 1.4%; p = 1.000). Both cohorts exhibited low frequencies of severe wound complications ranging between 1.4 and 1.9%. No major radiation toxicities were reported in either group. In the subgroup analysis, low-risk patients had significantly better mean scores in the subscales of inframammary fold and scar. Based on the BREAST-Q patient-reported outcomes questionnaire, seven out of nine parameters were scored similarly between both groups with no significant difference. Conclusion This study showed that the use of IORT in both low- and high-risk early breast cancers is efficacious and safe with low recurrence rates and an acceptable toxicity profile.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Quality-of-life, Conserving therapy, Surgery, Mastectomy, Trial, Boost, Irradiation, Experience, Carcinoma, Toxicity |
| Subjects: | R Medicine > RC Internal medicine |
| Divisions: | Faculty of Medicine > Clinical Oncology Department Faculty of Medicine > Nursing Science Department Faculty of Medicine > Social & Preventive Medicine Faculty of Medicine > Surgery Department |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 26 Jun 2023 06:33 |
| Last Modified: | 26 Jun 2023 06:33 |
| URI: | http://eprints.um.edu.my/id/eprint/39367 |
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