Wong, Pooi Fong and Murugan, Dharmani Devi and Ramasamy, Thamil Selvee (2023) Senotherapeutics for mesenchymal stem cell senescence and rejuvenation. Drug Discovery Today, 28 (1). ISSN 1359-6446, DOI https://doi.org/10.1016/j.drudis.2022.103424.
Full text not available from this repository.Abstract
Mesenchymal stem cells (MSCs) are susceptible to replicative senescence and senescence-associated functional decline, which hampers their use in regenerative medicine. Senotherapeutics are drugs that target cellular senescence through senolytic and senomorphic functions to induce apoptosis and suppress chronic inflammation caused by the senescence-associated secreted phenotype (SASP), respectively. Therefore, senotherapeutics could delay aging-associated degeneration. They could also be used to eliminate senescent MSCs during in vitro expansion or bioprocessing for transplantation. In this review, we discuss the role of senotherapeutics in MSC senescence, rejuvenation, and transplan-tation, with examples of some tested compounds in vitro. The prospects, challenges, and the way forward in clinical applications of senotherapeutics in cell-based therapeutics are also discussed.
| Item Type: | Article |
|---|---|
| Funders: | Universiti Malaya Impact-Oriented Interdisciplinary Research Grant (Grant No: IIRG001- 2020FNW), Universiti Malaya SATU Joint Research Scheme (Grant No: ST031-2020) |
| Uncontrolled Keywords: | Cellular senescence; Rejuvenation; Senolytics; Senomorphics; Stem cell therapy |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 29 Nov 2023 01:55 |
| Last Modified: | 29 Nov 2023 01:55 |
| URI: | http://eprints.um.edu.my/id/eprint/39315 |
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