Association of melanocortin-4 receptor gene polymorphisms with obesity-related parameters in Malaysian Malays

Apalasamy, Y.D.; Ming, M.F.; Rampal, S.; Bulgiba, A.; Mohamed, Z. (2012) Association of melanocortin-4 receptor gene polymorphisms with obesity-related parameters in Malaysian Malays. Ann Hum Biol. ISSN 1464-5033

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Abstract

Background: Melanocortin-4 receptor (MC4R) is an important regulator of body weight and energy intake. Genetic polymorphisms of the MC4R gene have been found to be linked to obesity in many recent studies across the globe. Aim: This study aimed to examine the effects of MC4R polymorphisms on obesity parameters, Linkage disequilibrium (LD) pattern and haplotypes in Malaysian Malays. Methods: The study subjects were 652 Malaysian Malays. Genomic DNA was extracted from buccal swabs. Genotyping was performed using Sequenom MassARRAY((R)) iPLEX platform. Anthropometric and blood lipid profiles were measured. Results: MC4R rs571312 SNP was associated with logBMI (p = 0.008) and systolic blood pressure (p = 0.005), while MC4R rs2229616 SNP was associated with total cholesterol (TC) levels (p = 0.016). The MC4R rs7227255 SNP did not show any association with obesity parameters. Conclusions: The strength of LD of the MC4R gene region is low and the haplotypes were not associated with obesity in Malaysian Malays.

Item Type: Article
Creators:
  1. Apalasamy, Y.D.
  2. Ming, M.F.
  3. Rampal, S.
  4. Bulgiba, A.(Department of Social and Preventive Medicine, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA)
  5. Mohamed, Z.
Journal or Publication Title: Ann Hum Biol
Additional Information: Apalasamy, Yamunah Devi Ming, Moy Foong Rampal, Sanjay Bulgiba, Awang Mohamed, Zahurin ENG 2012/09/20 06:00 Ann Hum Biol. 2012 Sep 18.
Uncontrolled Keywords: MC4R gene, SNP, Obesity, Linkage Disequilibrium, Haplotypes
Subjects: R Medicine
Divisions: UNSPECIFIED
Depositing User: Ms Haslinda Lahuddin
Date Deposited: 08 Nov 2012 12:03
Last Modified: 08 Nov 2012 12:03
URI: http://eprints.um.edu.my/id/eprint/3921

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