Fahim, Hoda and Mihankhah, Peyman and Khaligh, Nader Ghaffari (2023) Greener and scalable mechanosynthesis of bis(3-indolyl)methane as an example of versatile pharmaceutical scaffold: Is the mechanochemical technique a metal-free process? Synthetic Communications, 53 (2). pp. 146-159. ISSN 0039-7911,
Full text not available from this repository.Abstract
The metal-free feature of mechanosynthesis of bis(3-indolyl)methane derivatives using poly(4-vinyl pyridine), a commercially available functional polymer, by ball mill technique at ambient conditions was studied. The condensation of various carbonyl compounds with two indoles smoothly proceeded, and pure products were easily isolated in high to excellent yields. Poly(4-vinylpyridine) exhibited high recyclability without any loss of catalytic activity or change in the chemical structure. The influence of polymer MW with a certain PDI on the mechanosynthesis of BIMs was investigated. In addition, the effect of the ball and jar with zirconium oxide material was studied on the rate and yield of the BIMs synthesis process. The method was scalable and generated minimal hazardous wastes. Some merits of the current methodology are such as the good to high yields for various carbonyl compounds and avoiding the use of toxic, expensive, and metal-containing catalysts with a tedious process of preparation, separation, and purification.
| Item Type: | Article |
|---|---|
| Funders: | None |
| Uncontrolled Keywords: | Environmental protection; Multicomponent reaction; Solid-phase synthesis; Sustainable chemistry |
| Subjects: | Q Science > QC Physics Q Science > QD Chemistry |
| Divisions: | Universiti Malaya |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 27 Nov 2024 04:21 |
| Last Modified: | 27 Nov 2024 06:43 |
| URI: | http://eprints.um.edu.my/id/eprint/39202 |
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