Nassir, Che Mohd Nasril Che Mohd and Damodaran, Thenmoly and Ismail, Nurul Iman and Hashim, Sabarisah and Jaffer, Usman and Hamid, Hafizah Abdul and Mehat, Muhammad Zulfadli and Norazit, Anwar and Mustapha, Muzaimi (2023) The NLRP3 Inflammasome in Age-Related Cerebral Small Vessel Disease Manifestations: Untying the Innate Immune Response Connection. Life-Basel, 13 (1). ISSN 2075-1729, DOI https://doi.org/10.3390/life13010216.
Full text not available from this repository.Abstract
In this narrative review, we present the evidence on nucleotide-binding and oligomerization (NOD) domain-like receptor (NLR) family pyrin domain (PYD)-containing 3 (NLRP3) inflammasome activation for its putative roles in the elusive pathomechanism of aging-related cerebral small vessel disease (CSVD). Although NLRP3 inflammasome-interleukin (IL)-1 beta has been implicated in the pathophysiology of coronary artery disease, its roles in cerebral arteriothrombotic micro-circulation disease such as CSVD remains unexplored. Here, we elaborate on the current manifestations of CSVD and its' complex pathogenesis and relate the array of activators and aberrant activation involving NLRP3 inflammasome with this condition. These neuroinflammatory insights would expand on our current understanding of CSVD clinical (and subclinical) heterogenous manifestations whilst highlighting plausible NLRP3-linked therapeutic targets.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Cerebral small vessel disease; NLRP3 inflammasome; Cerebral ischemia; Therapeutics; Aging |
| Subjects: | R Medicine R Medicine > R Medicine (General) > Medical technology |
| Divisions: | Faculty of Medicine Faculty of Medicine > Biomedical Science Department |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 16 Oct 2024 08:17 |
| Last Modified: | 16 Oct 2024 08:17 |
| URI: | http://eprints.um.edu.my/id/eprint/39064 |
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