Prakoso, Akbar Teguh and Basri, Hasan and Adanta, Dendy and Yani, Irsyadi and Ammarullah, Muhammad Imam and Akbar, Imam and Ghazali, Farah Amira and Syahrom, Ardiyansyah and Kamarul, Tunku (2023) The Effect of Tortuosity on Permeability of Porous Scaffold. Biomedicines, 11 (2). ISSN 2227-9059, DOI https://doi.org/10.3390/biomedicines11020427.
Full text not available from this repository.Abstract
In designing porous scaffolds, permeability is essential to consider as a function of cell migration and bone tissue regeneration. Good permeability has been achieved by mimicking the complexity of natural cancellous bone. In this study, a porous scaffold was developed according to the morphological indices of cancellous bone (porosity, specific surface area, thickness, and tortuosity). The computational fluid dynamics method analyzes the fluid flow through the scaffold. The permeability values of natural cancellous bone and three types of scaffolds (cubic, octahedron pillar, and Schoen's gyroid) were compared. The results showed that the permeability of the Negative Schwarz Primitive (NSP) scaffold model was similar to that of natural cancellous bone, which was in the range of 2.0 x 10(-11) m(2) to 4.0 x 10(-10) m(2). In addition, it was observed that the tortuosity parameter significantly affected the scaffold's permeability and shear stress values. The tortuosity value of the NSP scaffold was in the range of 1.5-2.8. Therefore, tortuosity can be manipulated by changing the curvature of the surface scaffold radius to obtain a superior bone tissue engineering construction supporting cell migration and tissue regeneration. This parameter should be considered when making new scaffolds, such as our NSP. Such efforts will produce a scaffold architecturally and functionally close to the natural cancellous bone, as demonstrated in this study.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Bone tissue engineering; Porous scaffold; Tortuosity; Permeability; Computational fluid dynamics |
| Subjects: | R Medicine R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 16 Oct 2024 07:30 |
| Last Modified: | 16 Oct 2024 07:30 |
| URI: | http://eprints.um.edu.my/id/eprint/38729 |
Actions (login required)
 |
View Item |
