Yusefi, Mostafa and Shameli, Kamyar and Lee-Kiun, Michiele Soon and Teow, Sin-Yeang and Moeini, Hassan and Ali, Roshafima Rasit and Kia, Pooneh and Jie, Chia Jing and Abdullah, Nurul Hidayah (2023) Chitosan coated magnetic cellulose nanowhisker as a drug delivery system for potential colorectal cancer treatment. International Journal of Biological Macromolecules, 233. ISSN 0141-8130, DOI https://doi.org/10.1016/j.ijbiomac.2023.123388.
Full text not available from this repository.Abstract
Polysaccharide-based magnetic nanocomposites can eminently illuminate several attractive features as anticancer drug carriers. In this study, rice straw-based cellulose nanowhisker (CNW) was used as solid support for Fe3O4 nanofillers to synthesize magnetic CNW. Then, cross-linked chitosan-coated magnetic CNW for 5-fluorouracil carrier abbreviated as CH/MCNW/5FU. Fourier-transform infrared, X-Ray diffraction, and X-ray photoelectron spectroscopy analysis indicated successful fabrication and multifunctional properties of the CH/MCNW/ 5FU nanocomposites. In addition, CH/MCNW/5FU nanocomposites showed hydrodynamic diameter and zeta potential value of 181.31 +/- 3.46 nm and +23 +/- 1.8 mV, respectively. Based on images of transmission electron microscopy, magnetic CNW as reinforcement was coated with chitosan to obtain almost spherical CH/MCNW/ 5FU nanocomposites with an average diameter of 37.16 +/- 3.08. The nanocomposites indicated desired saturation magnetization and thermal stability, high drug encapsulation efficiency, and pH-dependent swelling and drug release performance. CH/MCNW/5FU nanocomposites showed potent killing effects against colorectal cancer cells in both 2D monolayer and 3D spheroid models. These findings suggest CH/MCNW as a potential carrier for anticancer drugs with high tumour-penetrating capacity.
| Item Type: | Article |
|---|---|
| Funders: | Takasago Thermal Engineering Co. Ltd., Sunway University Internal Grant Scheme 2022 (R.K.130000.7343.4B422), Sunway University Internal Grant Scheme 2022 (GRTIN-IGS-DMS (S)-04-2022) |
| Uncontrolled Keywords: | Polysaccharides; Magnetic nanocomposites; Drug delivery systems; Cytotoxicity assay; Colorectal cancer |
| Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology |
| Divisions: | Faculty of Science > Institute of Biological Sciences |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 27 Jun 2023 06:35 |
| Last Modified: | 27 Jun 2023 06:35 |
| URI: | http://eprints.um.edu.my/id/eprint/38627 |
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