Genetic study of 12 X-STRs in Malay population living in and around Kuala Lumpur using Investigator Argus X-12 kit

Samejima, M.; Nakamura, Y.; Nambiar, P.; Minaguchi, K. (2012) Genetic study of 12 X-STRs in Malay population living in and around Kuala Lumpur using Investigator Argus X-12 kit. International Journal of Legal Medicine, 126 (4). pp. 677-683. ISSN 0937-9827

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      Abstract

      We investigated 12 X-chromosomal short tandem repeat (STR) polymorphisms in 283 unrelated Malay individuals (160 males and 123 females) living in and around Kuala Lumpur using the Investigator Argus X-12 kit. Heterozygosity among the present 12 X-STRs showed a distribution of from 55.3 to 93.5 . The diversity values of the haplotypes constructed using four closely linked groups were all higher than 0.9865. A comparison of allelic frequency in each system and haplotype variation indicated that the nature of these X-STRs in the Malay population differed from that in East Asian, European, or African populations. Several microvariant alleles found in the Malay population were characterized and compared with known sequence data. The present data may be helpful in forensic casework such as personal identification and kinship testing in the Malay population in Malaysia.

      Item Type: Article
      Journal or Publication Title: International Journal of Legal Medicine
      Additional Information: ISI Document Delivery No.: 962SN Times Cited: 0 Cited Reference Count: 20 Samejima, Michinaga Nakamura, Yasutaka Nambiar, Phrabhakaran Minaguchi, Kiyoshi Ministry of Education, Science, Sports and Culture22592345 The authors would like to thank Associate Professor Jeremy Williams, Tokyo Dental College, for his assistance with the English of this manuscript. This research was partially supported by the Ministry of Education, Science, Sports and Culture, Grant-in-Aid for Scientific Research (C) (22592345). Springer New york
      Uncontrolled Keywords: X chromosome STR Malay Argus X-12 Microvariant allele Closely linked group linkage groups powerful tool provides markers region
      Subjects: R Medicine > RK Dentistry
      Divisions: Faculty of Dentistry > Dept of General Dental Practice And Oral & Maxillofacial Imaging
      Depositing User: Mr Ahmad Azwan Azman
      Date Deposited: 07 Nov 2012 10:17
      Last Modified: 07 Nov 2012 10:17
      URI: http://eprints.um.edu.my/id/eprint/3860

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