Poly-(MMA-IL) filter paper: A new class of paper-based analytical device for thin-film microextraction of multi-class antibiotics in environmental water samples using LC-MS/MS analysis

Shahriman, Mohamad Shariff and Mohamad, Sharifah and Mohamad Zain, Nur Nadhirah and Raoov, Muggundha (2023) Poly-(MMA-IL) filter paper: A new class of paper-based analytical device for thin-film microextraction of multi-class antibiotics in environmental water samples using LC-MS/MS analysis. Talanta, 254. ISSN 0039-9140, DOI https://doi.org/10.1016/j.talanta.2022.124188.

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Abstract

A paper-based polymeric ionic liquid (p-Poly-(MMA-IL)) was successfully developed by grafting the polymeric ionic liquid on the surface of commercial filter paper (FP) by using the dipping method, presenting a new cost-effective film. The newly developed p-Poly-(MMA-IL) FP was then applied as a paper-based thin-film microextraction (p-TFME) analytical device to extract 14 compounds as representative of five groups of antibiotic drugs, which were sulfonamides, tetracyclines, fluoroquinolones, penicillin and macrolides in environmental water samples. Besides, p-Poly-(MMA-IL) FP, p-Poly-(MMA) FP, and unmodified filter paper were successfully characterised by FTIR, NMR, FESEM, TGA, and XRD techniques. They underwent significant parameters optimisation, which affected the extraction efficiency. Under optimal conditions, the proposed (p-Poly-(MMA-IL) FP-TFME) device method was evaluated and applied to analyse multi-class antibiotic drugs in environmental water samples by using a liquid chromatography-mass spectrometry (LC-MS). The validation method showed that a good linearity (0.1 mu g L-1 - 500 mu g L-1) was noted (R-2 > 0.993, n = 3). Detection and quantification limits were within 0.05 mu g L-1 - 4.52 mu g L-1 and 0.15 mu g L-1 - 13.6 mu g L-1, respectively. The relative standard deviation (RSD) values ranged at 1.4%-12.2% (intra-day, n = 15) and 4.4%-11.0% (inter-day, n = 10). The extraction recoveries of environmental water samples ranged from 79.1% to 126.8%, with an RSD of less than 15.4% (n = 3). The newly developed paper-based polymeric ionic liquid (p-Poly-(MMA-IL) FP) for analysis of multi-class antibiotic drugs under the p-TFME analytical device procedure was successfully achieved with limited sample volume and organic solvent, fast extraction, and feasible in daily analysis. The detection concentration and relative RSD of multi-class antibiotics determined in various environmental water samples by the proposed method (n = 5) were within 0.44 mu g L-1 - 54.41 mu g L 1 and 0.69%-15.56%, respectively. These results signified the potential of the p-Poly-(MMA-IL) FP-TFME device as an efficient, sensitive and environmentally friendly approach for analysing antibiotics.

Item Type: Article
Funders: Ministry of Higher Education, Malaysia (Grant no. FRGS/1/2020/STG04/UM/02/9), Universiti Malaya, Universiti Sains Malaysia
Uncontrolled Keywords: Paper-based materials; Polymeric ionic liquid; Multi-class antibiotic drugs; Thin-film microextraction; Liquid chromatography-mass spectrometry; Environmental water samples
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science > Department of Chemistry
Depositing User: Ms Zaharah Ramly
Date Deposited: 28 Jun 2025 07:34
Last Modified: 28 Jun 2025 07:34
URI: http://eprints.um.edu.my/id/eprint/38554

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