Perumalsamy, Sangeetha and Zaman Huri, Hasniza and Abdullah, Bashar Mudhaffar and Mazlan, Othman and Wan Ahmad, Wan Azman and Vethakkan, Shireene Ratna D. B. (2023) Genetic markers of insulin resistance and atherosclerosis in type 2 diabetes mellitus patients with coronary artery disease. Metabolities, 13 (3). ISSN 2218-1989, DOI https://doi.org/10.3390/metabo13030427.
Full text not available from this repository.Abstract
Type 2 diabetes mellitus (T2DM) is characterized by impaired insulin secretion on a background of insulin resistance (IR). IR and T2DM are associated with atherosclerotic coronary artery disease (CAD). The mechanisms of IR and atherosclerosis are known to share similar genetic and environmental roots. Endothelial dysfunction (ED) detected at the earliest stages of IR might be the origin of atherosclerosis progression. ED influences the secretion of pro-inflammatory cytokines and their encoding genes. The genes and their single nucleotide polymorphisms (SNPs) act as potential genetic markers of IR and atherosclerosis. This review focuses on the link between IR, T2DM, atherosclerosis, CAD, and the potential genetic markers CHI3L1, CD36, LEPR, RETN, IL-18, RBP-4, and RARRES2 genes.
| Item Type: | Article |
|---|---|
| Funders: | Universiti Malaya Research, Universiti Malaya, UMRP024B-14HTM, UMRP024C-14HTM |
| Uncontrolled Keywords: | Insulin resistance; Type 2 diabetes mellitus; Atherosclerosis; Endothelial dysfunction; Coronary artery disease; Genetic markers; Single nucleotide polymorphisms |
| Subjects: | R Medicine > RC Internal medicine |
| Divisions: | Faculty of Medicine Faculty of Medicine > Medicine Department |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 30 Nov 2023 06:09 |
| Last Modified: | 30 Nov 2023 06:09 |
| URI: | http://eprints.um.edu.my/id/eprint/38539 |
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